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Old 08-24-2012
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Question Gastric Ulcer + Renal Stones!

A patient comes to medical attention for evaluation of a renal stone....on physical examination physician comes to know about the pt's past history of peptic ulcers.
Which diagnosis you suspect?

a) Sarcoidosis
b) Sipple syndrome
c) Shy dragger syndrome
d) Sturge weber syndrome
e) Wermer syndrome
f) Turcot syndrome
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  #2  
Old 08-24-2012
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Would be E, it's MEN 1 which's 3P (Pituitary, Pancreatic mainly Gastrinoma, and parathyroid).
A is associated with hypercalcemia but i don't think to a degree can cause ulceration.
B is MEN 2 which's medullary cancer of thyroid, pheochromocytome and parathyroid hyperplasia.
C don't know about it
D is congenital condition assocaited with MR, port wine stain.
F is associated with polyp formation not hypercalcemia and peptic ulceration.
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Old 08-24-2012
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e
wermer's syndrome,men 1-parathyroid tumors,pituitary tumors,pancreatic endocrine tumors-zollinger-ellison syndrome ,insulinomas,vipomas,glucagonomas;commonly present with renal stones and stomach ulcers
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Old 08-25-2012
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Post E is the answer

E is the most appropriate answer

actually, both A and E are true.....sarcoidosis can also cause peptic ulcers in rare sequelae..so, wermer syndrome would be appropriate

wermer( 3 P's)----parathyroid,pancreas(islet cell tumors),pituitary
sipple------MEN 2a---parathyroid hyperplasia,medullary ca. of thyroid,pheochromocytoma

shydragger syndrome---autonomic nervous system dysfunction...rare disease
sturge weber------portwine stain ,leptomeningeal angiokeratomas
turcot------aut. recessive,FAP+ astrocytoma's

and a high yield point of gastrinoma in MEN 1---it is the carcinoid tumor arising from the islet cells(so, it secrete serotonin too)
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Endocrine-, Pathology-, Step-1-Questions, Syndromes-Acronyms

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