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Old 08-25-2012
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RBC Sickle Cell Anemia

A well notable hematologist on his way of presentation of anemia's..tells the public that sickle cell anemia incidence has been increasing since last 10 yrs...it is caused by the missense mutation of valine in glutamic acid in 6th position in globin chain...it occurs by autosomal recessive inheritance so, he warns the people for prenatal screening for its earlier diagnosis...as the disease is concerned..which of the following statements are inappropriate with the sickle cell disease?

a) a crew cut appearance is seen on skull x-ray
b) only heterozygotes develop resistance against malaria
c) watery diarrhea is associated with increase in number of sickled cells
d) a neonate with dactylitis can be due to sickle cell anemia.
e) sloughing of renal papilla is its complication..
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Old 08-25-2012
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Cc.............................
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Old 08-25-2012
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Default b) only heterozygotes develop resistance against malaria

correct me if i am wrong.
If heterozygotes are resistance against malaria why no homozygotes.
WHY THIS RACISM...hehehe
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Old 08-25-2012
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Default my answer

c) watery diarrhea is associated with increase in number of sickled cells
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Old 08-25-2012
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Would go with B
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Old 08-25-2012
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The protective effect of sickle cell trait does not apply to people with sickle cell disease
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Old 08-25-2012
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Quote:
Originally Posted by koolkiller88 View Post
correct me if i am wrong.
If heterozygotes are resistance against malaria why no homozygotes.
WHY THIS RACISM...hehehe
That is called the "Heterozygous advantage" in pxts with sickle cell trait.it confers a large immunity against p.falciparum but not total resistance to malaria.Homozygotes don't have this advantage .
Also seen in thalassemia.I don't know the pathophysiology though
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Old 08-25-2012
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Quote:
Originally Posted by imgchuchu View Post
That is called the "Heterozygous advantage" in pxts with sickle cell trait.it confers a large immunity against p.falciparum but not total resistance to malaria.Homozygotes don't have this advantage .
Also seen in thalassemia.I don't know the pathophysiology though
I have read this too in fact it is recommended to patients with sickle cell disease living in malarial countries to receive an anti-malarial chemoprophylaxis

I'll go with c too
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Old 08-25-2012
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First I wanted to go with B when I saw Malaria but watery diarrhia sounded much better.lol

So I will go with C.
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Old 08-26-2012
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Post D is the right answer

guys, the correct answer is D) a neonate with dactylitis can be due to sickle cell anemia....
sounds weird, but it's the right answer
a neonate can be present with dactylitis but not due to sickle cell....coz in newborn HbF will be present to mask the sickle cell symptoms....so, dactylitis is only present after 6-9 months of birth.........

as for the other options.....

a) a crew cut appearance in skull xray ----is seen with SCA ( and also with beta thalassemia

b) only heterozygotes can develop malaria resistance----yes, and is also feature of beta thalassemia trait( not thalassemia major)...

c)watery diarrhea is associated with increase in number of sickled cells------yes, watery diarrhea lead to dehydration..dehydration(also low o2) can lead to HbS polymerization-----increase in sickling or number of sickled cells

e)sloughing of renal papilla
---yes, renal papillary necrosis is its sequela

so,this is the reason hydroxyures is given to sickle cell pts....they increase Hbf
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Old 08-26-2012
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[QUOTE=venky2600;142446]guys, the correct answer is D) a neonate with dactylitis can be due to sickle cell anemia....
sounds weird, but it's the right answer


So the magic word here is "neonate"?that's a wicked question
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c) watery diarrhea is associated with increase in number of sickled cells
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Quote:
Originally Posted by riya_rai84 View Post
c) watery diarrhea is associated with increase in number of sickled cells
oh dehydration,i forget about this
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[QUOTE=venky2600;142446]guys, the correct answer is D) a neonate with dactylitis can be due to sickle cell anemia....
sounds weird, but it's the right answer
a neonate can be present with dactylitis but not due to sickle cell....coz in newborn HbF will be present to mask the sickle cell symptoms....so, dactylitis is only present after 6-9 months of birth.........[Quote]


http://en.wikipedia.org/wiki/Dactylitis

Dactylitis can occur in seronegative arthropathies, such as psoriatic arthritis and ankylosing spondylitis, in sickle-cell disease as result of a vasoocclusive crisis with bone infarcts, and in infectious conditions including tuberculosis and leprosy.
In sickle-cell disease it is manifested for the first time between 6-9 month old infants.
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[QUOTE=riya_rai84;142473][QUOTE=venky2600;142446]guys, the correct answer is D) a neonate with dactylitis can be due to sickle cell anemia....
sounds weird, but it's the right answer
a neonate can be present with dactylitis but not due to sickle cell....coz in newborn HbF will be present to mask the sickle cell symptoms....so, dactylitis is only present after 6-9 months of birth.........
Quote:


http://en.wikipedia.org/wiki/Dactylitis

Dactylitis can occur in seronegative arthropathies, such as psoriatic arthritis and ankylosing spondylitis, in sickle-cell disease as result of a vasoocclusive crisis with bone infarcts, and in infectious conditions including tuberculosis and leprosy.
In sickle-cell disease it is manifested for the first time between 6-9 month old infants.
yes, thank you for reference.....i came to knew this information from....dr.najeeb videos....
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[QUOTE=venky2600;142486][QUOTE=riya_rai84;142473]
Quote:
Originally Posted by venky2600 View Post
guys, the correct answer is D) a neonate with dactylitis can be due to sickle cell anemia....
sounds weird, but it's the right answer
a neonate can be present with dactylitis but not due to sickle cell....coz in newborn HbF will be present to mask the sickle cell symptoms....so, dactylitis is only present after 6-9 months of birth.........

yes, thank you for reference.....i came to knew this information from....dr.najeeb videos....
really? I need to see those videos
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  #17  
Old 08-26-2012
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[QUOTE=debs;142489][QUOTE=venky2600;142486]
Quote:
Originally Posted by riya_rai84 View Post

really? I need to see those videos
yup,those videos are awesome....but u shuld see them if u have enough time with exam....coz those videos are way too slow..i saw them with nearly 1.7x speed..but i covered only some of the topics from those lectures as i didnt have sufficient time
but they are really worth watching..
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