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Old 08-26-2012
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Default eosinophil chemotaxis

A 24 yr old male presents to your office complaining of paroxysmal episodes of breathlessness and wheezing sputum microscopy shows many granule containing cels and crystalloid masses. The sputum findings suggest the role of which of the folowing substance substances in this patients condition.

a) IL1
b) IL2
c)IL3
d) IL4
e) IL5
f) Y interferron
g) TGF B...
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Old 08-26-2012
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Default my answer

d) IL4.....
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Old 08-26-2012
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Default

Ee..IL5
functions for eosinophil chemotaxis,plasma and IgA differentiation
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Old 08-26-2012
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Post D)IL4

i would like to go with d)IL4
coz, Ig E( from IL4) produced initially for the response of bronchoconstriction which on reexposure lead eosinophil production(IL5) and mast cell recruitment...
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Old 08-26-2012
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on a second thought imgchuchu is right.
IL4 is for class switching to IgE, IL5 is for eaosinophils production (found in the sputum).

so the answer should be e) IL5
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Old 08-26-2012
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Post

Quote:
Originally Posted by venky2600 View Post
i would like to go with d)IL4
coz, Ig E( from IL4) produced initially for the response of bronchoconstriction which on reexposure lead eosinophil production(IL5) and mast cell recruitment...
i want to change my answer to e) IL5....
as the question mentioned about granules and crystals.....
IL5----takes role in IgA and eosinophils release
IL4-----Ig E and Ig G------E>G
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Old 08-26-2012
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Default Nice question D. IL-4

Had to refer goljian's
according to Rapid review

Inhaled antigen stimulate induction of CD4 Th2 cells that release IL4 and IL-5.
IL-4: stimulate class switching of IgE
IL-5: stimulate production and activation of eosinophils

Inhaled antigen cross-link with IgE antibodies on mast cells and release histamines.
Where as in Late phase (4-8hrs later) eotaxin do chemotaxis for eosinophils and activates eosinophils.

Eosinophil granules produces Charcot leyden crystals (mentioned in question)
So, By all these what i concluded that
IL-5 stimulate activation of eosinophils and lead to these crystal mass formation.
Whereas, IgE (stimulated by IL-4) cross link with mast cells and cause all bronchioconstriction, mucus production. So, sputum finding will suggest IL-4 involvement.
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Old 08-26-2012
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Default

Yea Guyz it also got me confused cuz i thought it was IL4 sorry 4 d late response .. it's a UW question.


Paroxysmal breathlessness and wheezing in a young patient that is unrelated to the ingestion of aspirin, pulmonary infection, inhalation of irritant, stress and/or exercise should raise a strong suspicion for Extrinsic allergic asthma classical sputum findings include eosinophils, and charcot leyden crystals. Eosinophils are recruited and activated by IL5 secreted by TH2 Type helper T cells.

release of IL4 by TH2 helper type T cells is a non specific pathway involved in the stimulation of B cell antibody production. IL4 is not chemotactic for eosinophils
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