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Old 08-29-2012
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Biochemistry Alcoholic Biochemistry Case

A 62 year old male alchoholic is brought to emergency room acting very confused. Physical examination reveals a thin and emaciated male who has problems with memory, ataxia and paralysis of extraocular muscles. Extensive work up reveals atrophy and small hemorrhages in the periventricular region of his brain and around the mamillary bodies.
These signs and symptoms are most consistent with the deficiency of :-

a) Biotin
b) Riboflavin
c) Selenium
d) Pyridoxine
e) Thiamine
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Old 08-29-2012
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e. Thiamine
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Old 08-29-2012
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by the way the dx is Wernicke-Korsakoff syndrome
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Old 08-29-2012
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Default my answer :)

e) Thiamine
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Old 08-29-2012
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e) thiamine----wernicke korsakoff syndrome...
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Old 08-29-2012
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this is primary biochemi doubt usmle will go this cheap
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Old 08-29-2012
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Classic USMLE question.
It's thiamine


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Old 08-30-2012
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dangggg, if only all the questions were like this...
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Old 08-30-2012
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Quote:
Originally Posted by BritneySpears View Post
dangggg, if only all the questions were like this...
haha if only
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Old 08-30-2012
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The correct answer is e.) Thiamine
Thiamine defeciency may produce the CNS symptoms of Wernicke-Korsakoff syndrome.Wenicke's encephalopathy consists of mainly foci of hemmorhages and necrosis in the mamillary bodies and the ventricular regions of the thalamus and the hypothalamus,about the aqueduct in the midbrain and in the floor of fourth ventricle.
Symptoms of Wernicke's Syndrome include progressive dementia(confusion),ataxia,paralysis of extraocular muscles-often with bilateral rectus or sixth nerve palsy.
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