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Old 09-03-2012
koolkiller88's Avatar
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Biochemistry Arginase deficiency

I came across an explanation in UW related to arginase def. Bit confused in it- So would like an opinion.

treatment of arginase def.-
1. Low protein diet that is devoid of arginine (make sense, i accept)

2. Administration of synthetic protein made of essential amino acids usually results in dramastic decrease in plasma arginine concentration and an improvemment in neurological abnormalities.

Ya here i am confused how a essential amino acid diet (as arginine is also an amino acid) can decrease plasma arginine????

Is it a mistake or i am missing a basic concept here.
Thanks for opinion.
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Old 09-03-2012
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what i know is....arginine is only essential amino acid during positive nitrogen balance

dietary deficiency of even one essential amino acid lead to negative nitogen balance...(so arginine not required)
as arginase is deficient,arginine is deficient.....so, if synthetic protein is given.as arginine is not essential it's concentration decreases

but,i'm not sure .....

Last edited by venky2600; 09-03-2012 at 01:14 AM.
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Old 09-03-2012
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Quote:
Originally Posted by venky2600 View Post
what i know is....arginine is only essential amino acid during positive nitrogen balance

dietary deficiency of even one essential amino acid lead to negative nitogen balance...(so arginine not required)
as arginase is deficient,arginine is deficient.....so, if synthetic protein is given.as arginine is not essential it's concentration decreases

but,i'm not sure .....
i guess, synthetic protein you were referring is arginine free...
this might be helpful for u.
http://www.idph.state.ia.us/genetics/common/pdf/arg.pdf
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Old 09-03-2012
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Quote:
Originally Posted by venky2600 View Post
i guess, synthetic protein you were referring is arginine free...
this might be helpful for u.
http://www.idph.state.ia.us/genetics/common/pdf/arg.pdf
Ya that makes sense. If they would have wrote "synthetic protein". I would have thought of that but they mentioned synthetic made of essential amino acid. That made me confused. Anyways thanks for answering.
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Old 09-03-2012
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Quote:
Originally Posted by koolkiller88 View Post
Ya that makes sense. If they would have wrote "synthetic protein". I would have thought of that but they mentioned synthetic made of essential amino acid(arginine is no more essential in negative nitrogen balance). That made me confused. Anyways thanks for answering.
i think essential amino acid doesn't include arginine
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