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Old 09-06-2012
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Default Beta Blockers afterload reduction?

FA pg 307 says:

B-blockers reduce afterload, and increase EDV. Could some one explain this nicely?
Also, my understanding is that the Beta Blocker will decrease secretion of renin via B1 blockade. This would automatically block the vasoconstrictor effect of ATII on the afterload. But wouldn't a Beta blocker reduce preload also? Cause aldosterone is blocked as well?

And what about EDV? Would appreciate the help.
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Old 09-06-2012
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Quote:
Originally Posted by dockhi View Post
FA pg 307 says:

B-blockers reduce afterload, and increase EDV. Could some one explain this nicely?
Also, my understanding is that the Beta Blocker will decrease secretion of renin via B1 blockade. This would automatically block the vasoconstrictor effect of ATII on the afterload. But wouldn't a Beta blocker reduce preload also? Cause aldosterone is blocked as well?

And what about EDV? Would appreciate the help.

beta-blockers decrease the afterload due to blocking RAA pathway.
They're slowing down the heart rate so the diastole phase is longer hence increased EDV.

Last edited by Casandra; 09-06-2012 at 02:17 PM.
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dockhi (09-08-2012), pkul85 (09-15-2013), Wajahat (09-09-2012)
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Old 09-08-2012
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Thank you! Should add that to my FA
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