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Old 09-09-2012
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Biochemistry Glycolysis Question

Could someone please explain this question and answer. Thank you

A 44 year old alcoholic was brought to the emergency department by his friends. During their usual gathering at the local bar, he passed out and his friends were unable to revive him. The physician ordered an injection of Thiamine , followed by overnight parenteral glucose. The next morning the patient was alert and coherent, serum thiamine was normal, and blood glucose was 73 mg/dl (4mM). The patient was then sent home.

At the time of discharge from the hospital, which of the the following proteins would have no significant physiologic activity in this patient?

A) Malate Dehydrogenase
B) Glucokinase
C) alpha-ketoglutarage dehydrogenase
D) Glut 1 transporter
E) Phosphofructokinase-1

The answer is B . The only reason I can think why B would be correct is because Glucokinase has a high Km, and since blood glucose is 4mM this is why it has no activity.
Also, if IV glucose is maintaining the patients blood glucose, why is this still considered an overnight fast?
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Old 09-09-2012
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Glucokinase is induced by Insulin to phosphorylate excess glucose.
in this pxt,insulin will not be secreted at this glucose level hence nil glucokinase effect
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Old 09-10-2012
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Quote:
Originally Posted by sam2021 View Post
Could someone please explain this question and answer. Thank you

A 44 year old alcoholic was brought to the emergency department by his friends. During their usual gathering at the local bar, he passed out and his friends were unable to revive him. The physician ordered an injection of Thiamine , followed by overnight parenteral glucose. The next morning the patient was alert and coherent, serum thiamine was normal, and blood glucose was 73 mg/dl (4mM). The patient was then sent home.

At the time of discharge from the hospital, which of the the following proteins would have no significant physiologic activity in this patient?

A) Malate Dehydrogenase
B) Glucokinase
C) alpha-ketoglutarage dehydrogenase
D) Glut 1 transporter
E) Phosphofructokinase-1

The answer is B . The only reason I can think why B would be correct is because Glucokinase has a high Km, and since blood glucose is 4mM this is why it has no activity.
Also, if IV glucose is maintaining the patients blood glucose, why is this still considered an overnight fast?
HAHA...kaplan biochem notes question.
Ya the answer is B. glucokinase.
Reason:
think practically, person's glucose is 73 (below then normal limit). So at this time Do he need glucose storage or glucose consumption?
So glucokinase is an enzyme which traps glucose inside tissue so that it does diffuse out and helps in glucose storage.
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