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#1
09-04-2009
 USMLE Forums Newbie Steps History: Not yet Posts: 1 Threads: 1 Thanked 1 Time in 1 Post Reputation: 11
32 ATPs per glucose molecule?

Can anybody tell me how do we get 32 ATPs from each glucose molecule
I can't understand the calculation and also there's two questions about it in USMLE Consult
 The above post was thanked by: Usmle16Forall (09-15-2016)

#2
09-04-2009
 USMLE Forums Newbie Steps History: 1+CK+CS Posts: 4 Threads: 0 Thanked 7 Times in 2 Posts Reputation: 17

It can be 32 and it can be 30 depending on which shuttle

in the case of 32 here's the calculation:

Glycolysis 2 ATPs/glucose
if NADH enters through G3P shuttle it will yield 3 ATPs
so 2x3= 6 ATPs

Each glucose gives two pyruvates
Each pyruvate entering TCA will give off 12ATPs
so 12x2 = 24

24+6+2 = 32

am sure you'll understand how malate shuttle gives 30 ATPs instead

Last edited by StepTaker; 09-04-2009 at 12:39 AM. Reason: Formatting
 The above post was thanked by: anoop_1198 (07-05-2010), Dr.Lacune (08-19-2012), pradeeprox (04-08-2012), swwal (05-16-2015), tootsie (04-07-2012), Usmle16Forall (09-15-2016)
#3
10-13-2009
 USMLE Forums Master Steps History: 1+CK+CS+3 Posts: 742 Threads: 137 Thanked 2,462 Times in 441 Posts Reputation: 2565

Quote:
 Originally Posted by needtopass Each glucose gives two pyruvates
I think level1 confusion stems from the fact that he forgot that each glucose gives two pyruvates

Always remember the glycolysis equation

Code:
`Glucose + 2Pi + 2ADP + 2NAD = 2 Pyruvate + 2ATP + 2NADH + 2H + 2H2O`
 The above post was thanked by: anoop_1198 (07-05-2010), Dr.Lacune (08-19-2012), erickven (02-28-2016), pradeeprox (04-08-2012), swwal (05-16-2015), tootsie (04-07-2012), Usmle16Forall (09-15-2016)

#4
10-14-2009
 USMLE Forums Scout Steps History: 1+CK+CS+3 Posts: 46 Threads: 7 Thanked 56 Times in 11 Posts Reputation: 96
very good job ... but ....

Quote:
 Originally Posted by needtopass It can be 32 and it can be 30 depending on which shuttle in the case of 32 here's the calculation: Glycolysis 2 ATPs/glucose Glycolysis give 2 NADH if NADH enters through G3P shuttle it will yield 3 ATPs so 2x3= 6 ATPs Each glucose gives two pyruvates Each pyruvate entering TCA will give off 12ATPs so 12x2 = 24 Adding 24+6+2 = 32 am sure you'll understand how malate shuttle gives 30 ATPs instead

thats very cool but i think .. u all may forgot a step to convert pyruvate to Acetyl coA .. which yealds an Another mol. of NADH which add 3 ATP per pyruvate so Add 6 ATP per Gulcose which mean 1 Mol. of Glucose yealds 38 ATP per Glucose not 32 ATP

am i right ?!
 The above post was thanked by: forawee (12-05-2010), Laurentiu (11-28-2009), pradeeprox (04-08-2012), tootsie (04-07-2012)
#5
10-14-2009
 USMLE Forums Master Steps History: 1+CK+CS+3 Posts: 742 Threads: 137 Thanked 2,462 Times in 441 Posts Reputation: 2565

Quote:
 Originally Posted by Betro Sadek thats very cool but i think .. u all may forgot a step to convert pyruvate to Acetyl coA .. which yealds an Another mol. of NADH which add 3 ATP per pyruvate so Add 6 ATP per Gulcose which mean 1 Mol. of Glucose yealds 38 ATP per Glucose not 32 ATP am i right ?!
You are absolutely right
 The above post was thanked by: Laurentiu (11-28-2009)
#6
12-05-2010
 USMLE Forums Scout Steps History: Not yet Posts: 13 Threads: 3 Thanked 2 Times in 2 Posts Reputation: 12

You are absolutely right Betro. Glycolysis can produce either 6 or 8 ATPs, so by the end of KREBS CYCLE (36 or 38) depending on wt ATP produced from glycolysis.
#7
04-16-2011
 USMLE Forums Veteran Steps History: Step 1 Only Posts: 268 Threads: 14 Thanked 103 Times in 69 Posts Reputation: 113

Quote:
 Originally Posted by needtopass It can be 32 and it can be 30 depending on which shuttle in the case of 32 here's the calculation: Glycolysis 2 ATPs/glucose Glycolysis give 2 NADH if NADH enters through G3P shuttle it will yield 3 ATPs so 2x3= 6 ATPs Each glucose gives two pyruvates Each pyruvate entering TCA will give off 12ATPs so 12x2 = 24 Adding 24+6+2 = 32 am sure you'll understand how malate shuttle gives 30 ATPs instead
i think malate shuttle produces 3 atp s as it uses nadh and G3P shuttle produces 2 as it uses FADH2
#8
04-07-2012
 USMLE Forums Newbie Steps History: --- Posts: 1 Threads: 0 Thanked 0 Times in 0 Posts Reputation: 10

 Tags Biochemistry-

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