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  #1  
Old 09-04-2009
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Biochemistry 32 ATPs per glucose molecule?

Can anybody tell me how do we get 32 ATPs from each glucose molecule
I can't understand the calculation and also there's two questions about it in USMLE Consult
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Old 09-04-2009
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It can be 32 and it can be 30 depending on which shuttle

in the case of 32 here's the calculation:

Glycolysis 2 ATPs/glucose
Glycolysis give 2 NADH
if NADH enters through G3P shuttle it will yield 3 ATPs
so 2x3= 6 ATPs

Each glucose gives two pyruvates
Each pyruvate entering TCA will give off 12ATPs
so 12x2 = 24

Adding
24+6+2 = 32

am sure you'll understand how malate shuttle gives 30 ATPs instead

Last edited by StepTaker; 09-04-2009 at 12:39 AM. Reason: Formatting
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Old 10-13-2009
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Quote:
Originally Posted by needtopass View Post
Each glucose gives two pyruvates
I think level1 confusion stems from the fact that he forgot that each glucose gives two pyruvates

Always remember the glycolysis equation

Code:
Glucose + 2Pi + 2ADP + 2NAD = 2 Pyruvate + 2ATP + 2NADH + 2H + 2H2O
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  #4  
Old 10-14-2009
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Default very good job ... but ....

Quote:
Originally Posted by needtopass View Post
It can be 32 and it can be 30 depending on which shuttle

in the case of 32 here's the calculation:

Glycolysis 2 ATPs/glucose
Glycolysis give 2 NADH
if NADH enters through G3P shuttle it will yield 3 ATPs
so 2x3= 6 ATPs

Each glucose gives two pyruvates
Each pyruvate entering TCA will give off 12ATPs
so 12x2 = 24

Adding
24+6+2 = 32

am sure you'll understand how malate shuttle gives 30 ATPs instead

thats very cool but i think .. u all may forgot a step to convert pyruvate to Acetyl coA .. which yealds an Another mol. of NADH which add 3 ATP per pyruvate so Add 6 ATP per Gulcose which mean 1 Mol. of Glucose yealds 38 ATP per Glucose not 32 ATP

am i right ?!
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Old 10-14-2009
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Quote:
Originally Posted by Betro Sadek View Post
thats very cool but i think .. u all may forgot a step to convert pyruvate to Acetyl coA .. which yealds an Another mol. of NADH which add 3 ATP per pyruvate so Add 6 ATP per Gulcose which mean 1 Mol. of Glucose yealds 38 ATP per Glucose not 32 ATP

am i right ?!
You are absolutely right
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  #6  
Old 12-05-2010
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You are absolutely right Betro. Glycolysis can produce either 6 or 8 ATPs, so by the end of KREBS CYCLE (36 or 38) depending on wt ATP produced from glycolysis.
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Old 04-16-2011
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Quote:
Originally Posted by needtopass View Post
It can be 32 and it can be 30 depending on which shuttle

in the case of 32 here's the calculation:

Glycolysis 2 ATPs/glucose
Glycolysis give 2 NADH
if NADH enters through G3P shuttle it will yield 3 ATPs
so 2x3= 6 ATPs

Each glucose gives two pyruvates
Each pyruvate entering TCA will give off 12ATPs
so 12x2 = 24

Adding
24+6+2 = 32

am sure you'll understand how malate shuttle gives 30 ATPs instead
i think malate shuttle produces 3 atp s as it uses nadh and G3P shuttle produces 2 as it uses FADH2
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Old 04-07-2012
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doesnt the g3p shuttle produce 1,5 mol atp a nadh-->fadh2 conversion?
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