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Old 09-11-2012
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is turners XO a mechinism imprinting or am i going crazy?
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Old 09-11-2012
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Quote:
Originally Posted by pathophysio1 View Post
is turners XO a mechinism imprinting or am i going crazy?
I don't think Turner's Syndrome is coming out of gene impriting mechanism.

Gene imprinting is a gene expression phenomenon which is a process dependent upon its parental origin. Meaning: in human cells, expression of most of genes depends on the expression of both of the alleles. But some certain genes' expression are only contributed from the expression of the single allele instead of from both of two alleles. And which allele is silenced is determined by the gender. I mean if we know one of a specific gene's allele is inactivated in a child's father in A family, then the same gene's allele is also shut off in other male's genome in any other families. The rules also apply to gene imprinting in females.

Moving on to Turner's syndrome. It is the lost of one of X chromosome in female genome in most cases. It is not resulted from any gene inactivation. Furthermore, in normal female human beings, the inactivation of X chromosome is random, meaning you can not tell from which parent's X chromosome is shut off.

That is my personal understanding. Also welome any corrections and other commends.
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Old 09-11-2012
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i don't think 45,XO is due to imprinting
most commonly turner's is caused by early mitotic error leading to gonadal dysgenesis but most of them will die inutero.......
survival turner's are commonly due to mosaicism(45,XO and 1 normal 46,XX) than mitotic error.....
but if turner's with 45,XO and 46,XY then they are in risk of gonadoblastoma
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Thank you
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