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Old 09-18-2012
sruthi's Avatar
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Default nbme 5 doubt!!

gys!! cud ny1 pls explain d answer to me!! tnx

Q) wich of the following neurotransmitters is releasd in excess following ischemia and can initiate a receptor mediatd calcium influx that leads to neuronal death??
B. glutamate
C. glycine
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Old 09-18-2012
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Default From wikipedia


Overstimulation of glutamate receptors causes neurodegeneration and neuronal damage through a process called excitotoxicity. Excessive glutamate, or excitotoxins acting on the same glutamate receptors, overactivate glutamate receptors (specifically NMDARs), causing high levels of calcium ions (Ca2+) to influx into the postsynaptic cell.[34]

High Ca2+ concentrations activate a cascade of cell degradation processes involving proteases, lipases, nitric oxide synthase, and a number of enzymes that damage cell structures often to the point of cell death.[35] Ingestion of or exposure to excitotoxins that act on glutamate receptors can induce excitotoxicity and cause toxic effects on the central nervous system.[36] This becomes a problem for cells, as it feeds into a cycle of positive feedback cell death.
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