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Old 08-09-2010
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Biochemistry Mitochondrial Oxidative Phosphorylation Question!

Which of the following changes is most likely to be observed in mitochondria following the ingestion of a barbiturate?

A. Decreased activity of α-ketoglutarate dehydrogenase
B. Decreased lactate dehydrogenase activity
C. Decreased levels of hexokinase
D. Decreased levels of NADH
E. Decreased levels of NADPH

Please help me with this one. Thx in advance
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Old 08-09-2010
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is it b? it inhibits complex 1 of ETC.:sorry:
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Old 08-09-2010
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A Decreased activity of alpha;-ketoglutarate dehydrogenase
barbiturates inhibit NADH dehydrogenase..so increasing NADH n reduced NAD...
alpha keto glutarate req. NAD for its action....resulting in its decreased activity...
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Old 11-21-2011
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nice question
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Old 11-21-2011
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A. Decreased activity of α-ketoglutarate dehydrogenase
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