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 USMLE Step 1 Forum USMLE Step 1 Discussion Forum: Let's talk about anything related to USMLE Step 1 exam

#1
09-19-2012
 USMLE Forums Scout Steps History: 1+CK+CS Posts: 89 Threads: 17 Thanked 51 Times in 26 Posts Reputation: 61
NBME 7 question

hello there

for those who have taken NBME 7, there was a question in block 1 (I think!) depicting the relationship between the number of CAG repeats and the probability of disease. And there was an mRNA sequence for an individual who has 1 defected allele with 15 CAG repeats, with the other allele normally having 6 CAG repeats. The question is what is this individual's probability of getting the disease (huntigton's)

So in this case do we only consider the abnormal allele (15 repeats) or add the two together (21 repeats) to plot the probability ???

I'm sorry I don't remember the exact questions stem but definitely if you've seen it you'll know it !

#2
09-19-2012
 USMLE Forums Scout Steps History: Step 1 Only Posts: 28 Threads: 2 Thanked 5 Times in 2 Posts Reputation: 15
ans.

only consider the abnormal 15 repeats.

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