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  #1  
Old 09-21-2012
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Virus Female with AIDS

A 32-year-old woman with a 10-year history of intravenous drug use has developed a chronic watery diarrhea that has
persisted for the past week. On physical examination, she is afebrile and has mild muscle wasting. Her body mass index is
18. Laboratory studies of the stool show cysts of Cryptosporidium parvum. One month later, she develops cryptococcal
meningitis, which is treated successfully. Oral candidiasis is diagnosed 1 month later. This patient is at greatest risk of
developing which of the following neoplasms?

□ (A) Intestinal non-Hodgkin lymphoma
□ (B) Adenocarcinoma of the lung
□ (C) Leiomyosarcoma of retroperitoneum
□ (D) Cervical squamous carcinoma
□ (E) Cerebral astrocytoma
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Old 09-21-2012
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Default AA??????

AA...Reactivation of latent EBV??
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Old 09-21-2012
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□ (A) Intestinal non-Hodgkin lymphoma
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Old 09-21-2012
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Idea! A

Intestinal non-Hodgkin lymphoma
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Old 09-21-2012
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Default Stage 4 : I will go with

Cervical sq ca

She is prone for CNS lymphoma
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Old 09-21-2012
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Quote:
Originally Posted by MedicalExaminer View Post
A 32-year-old woman with a 10-year history of intravenous drug use has developed a chronic watery diarrhea that has
persisted for the past week. On physical examination, she is afebrile and has mild muscle wasting. Her body mass index is
18. Laboratory studies of the stool show cysts of Cryptosporidium parvum. One month later, she develops cryptococcal
meningitis, which is treated successfully. Oral candidiasis is diagnosed 1 month later. This patient is at greatest risk of
developing which of the following neoplasms?

□ (A) Intestinal non-Hodgkin lymphoma
□ (B) Adenocarcinoma of the lung
□ (C) Leiomyosarcoma of retroperitoneum
□ (D) Cervical squamous carcinoma
□ (E) Cerebral astrocytoma
Ya EBV reactivation in immunocompromised individual
A. Intestinal non- Hodgkin lymphoma


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Old 09-21-2012
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Default my answer A

One of the common types of B cell NON HODGKIN LYMPHOMA is Diffuse Large B cell lymphoma (50% of adults w/NHL) --> derived from germinal center-->localized disease w/extranodal involvement : GI tract (AIDS) or maybe brain (EBV)
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Old 09-22-2012
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Default (a) 

A
Opportunistic infections in an intravenous drug abuser suggest a diagnosis of AIDS. The most common neoplasms
seen in association with AIDS are B cell non-Hodgkin lymphoma and Kaposi sarcoma. A rare tumor associated with AIDS
in children is leiomyosarcoma. Cervical dysplasias and carcinomas are increased in women with HIV infection, but such
lesions are less frequent than lymphoma. Lung cancers at this woman's age are uncommon in any circumstance.
Opportunistic infections of the brain and central nervous system lymphomas are common in patients with AIDS, but glial
neoplasms are not.
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