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  #1  
Old 09-24-2012
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Question Mechanism of action of Eicosonoids

Which of the following with regard to the mechanism of action of Eicosonoids is correctly matched ?

A) TXA 2..........broncho-constriction, uterine-contraction, arteriolar dilatation

B) PG E 2 ........broncho-dilatation, uterine-contractions, arteriolar dilatation

C) PG F 2a.......broncho-constriction, veno dilatation, arteriolar contraction, uterine contraction

D) PG I2..........broncho-dilatation, Sodium retention, Renin release
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Old 09-24-2012
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Will go with B!
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Old 09-25-2012
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yes, the appropriate answer is B) PGE2.....(again thinking errata has done mistake of changing it to vasoconstriction....but causes vasodilation.from many other sources....so it's the most appropriate one...)

A) TXA 2..........broncho-constriction,platelet aggregation, arteriolar constriction
B) PG E 2 ........broncho-dilatation, uterine-contractions, arteriolar dilatation

C) PG F 2a.......broncho-constriction, veno dilatation(not sure of this), arteriolar dilation, uterine contraction

D) PG I2..........broncho-dilatation, vasodilation, decrease platelet aggregation
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Old 09-25-2012
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Quote:
Originally Posted by venky2600 View Post
yes, the appropriate answer is B) PGE2.....(again thinking errata has done mistake of changing it to vasoconstriction....but causes vasodilation.from many other sources....so it's the most appropriate one...)

A) TXA 2..........broncho-constriction,platelet aggregation, arteriolar constriction
B) PG E 2 ........broncho-dilatation, uterine-contractions, arteriolar dilatation

C) PG F 2a.......broncho-constriction, veno dilatation(not sure of this), arteriolar dilation, uterine contraction

D) PG I2..........broncho-dilatation, vasodilation, decrease platelet aggregation
Hey can you tell me on which pg its given in FA?
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Quote:
Originally Posted by koolkiller88 View Post
Hey can you tell me on which pg its given in FA?
it's in musculoskeletal pharma.....dont know exactly page guessing around 422pg
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Old 09-25-2012
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koolkiller, it's right at the end of musculoskeletal before drugs.
Venky, I checked my answer and thought I got it wrong. I guess the vasodilation part was contradictory. Has the errata changed it?
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Quote:
Originally Posted by dockhi View Post
koolkiller, it's right at the end of musculoskeletal before drugs.
Venky, I checked my answer and thought I got it wrong. I guess the vasodilation part was contradictory. Has the errata changed it?
yes, its changed to vasoconstriction ...but i checked in wiki ,googled---vasodilation is right one...they changed for both pge2 and pgf2alpha
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Quote:
Originally Posted by venky2600 View Post
yes, its changed to vasoconstriction ...but i checked in wiki ,googled---vasodilation is right one...they changed for both pge2 and pgf2alpha
Thanks! And vasodilation for both PGE2 and PGf2f-alpha, right?
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Quote:
Originally Posted by venky2600 View Post
it's in musculoskeletal pharma.....dont know exactly page guessing around 422pg
Mine FA is 2012 and its a complete arachidonic acid cycle given at pg 429 but the errata i got doesn't mention any error on this page.

TXA2- increase vascular tone (what should i consider- arteriolar dilator or veno dilator or both),

And it says PGE2 and PGF2alpha both have same properties- they are bronchodilators (but u mentioned one is broncho dilator and other is constrictor)

So ????????/
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Old 09-25-2012
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nice post..

add on
PG E1
misoprostol Rx for NSAID induced gastritis, MTP(with mifepritone an antiprogestogen)
Alprostadil to maintain Ductus arteriosus patent sply in TGA
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Old 09-25-2012
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Quote:
Originally Posted by koolkiller88 View Post
Mine FA is 2012 and its a complete arachidonic acid cycle given at pg 429 but the errata i got doesn't mention any error on this page.

TXA2- increase vascular tone (what should i consider- arteriolar dilator or veno dilator or both),

So ????????/
thanks dude for reminding again...sorry my mistake:sorry:...ya ,they changed only for PGF2alpha

A) TXA 2..........broncho-constriction,platelet aggregation, arteriolar constriction
B) PG E 2 ........broncho-dilatation(came to know from google but not sure), uterine-contractions, arteriolar dilatation

C) PG F 2a.......broncho-constriction, veno dilatation, arteriolar dilatation, uterine contraction

D) PG I2..........broncho-dilatation, vasodilation, decrease platelet aggregation


TXA2 is vasoconstrictor(arterial) for sure(in kaplan)....must be venodilator

@dockhi ---i think F.A confused the data little bit...better to follow kaplan for it
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