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Old 09-25-2012
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Arrow Belindalimm Daily Questions: Pathology #15

A 42-year-old women comes to the doctor's office, aiming to find out a way to reduce the wrinkles on her face. She was previously a super model. Replying to the patient's request, the doctor recommends injection of botulinum toxin. Which of the following best explain the mechanism of the toxin?

A. Prevents motor neuron secretory vesicle fuse with neuronal membrane
B. Blocks nicotinic aceytlcholine receptors
C. Inhibits Ca2++ release from SR
D. Inhibits choline uptake into motor neurons
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Old 09-25-2012
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Default D

Quote:
Originally Posted by belindalimm View Post
A 42-year-old women comes to the doctor's office, aiming to find out a way to reduce the wrinkles on her face. She was previously a super model. Replying to the patient's request, the doctor recommends injection of botulinum toxin. Which of the following best explain the mechanism of the toxin?

A. Prevents motor neuron secretory vesicle fuse with neuronal membrane
B. Blocks nicotinic aceytlcholine receptors
C. Inhibits Ca2++ release from SR
D. Inhibits choline uptake into motor neurons
D is the answer
Botulinum Toxin A, prevent the ACh release, blocking temporarily the transmission of the nerve impulse in the neuromuscular junction.
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Old 09-25-2012
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D. by blocking ACH reuptake.
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Old 09-25-2012
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A is the answer
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Old 09-25-2012
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Default A

Quote:
Originally Posted by belindalimm View Post
A 42-year-old women comes to the doctor's office, aiming to find out a way to reduce the wrinkles on her face. She was previously a super model. Replying to the patient's request, the doctor recommends injection of botulinum toxin. Which of the following best explain the mechanism of the toxin?

A. Prevents motor neuron secretory vesicle fuse with neuronal membrane
B. Blocks nicotinic aceytlcholine receptors
C. Inhibits Ca2++ release from SR
D. Inhibits choline uptake into motor neurons
I would go with
A. prevents motor neuron secretory vesicle fuse with neuronal membrane.
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A because it prevent the vesicles that contain acetyl choline from release...
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Old 09-26-2012
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Idea! A

* Hemicholinium is the drug that blocks the reuptake of choline.

  • The botulism neurotoxin is one of the most potent, lethal substances known.
  • Botulism is a disease caused by this neurotoxin
  • The neurotoxin is produced by bacteria called Clostridium botulinum.
  • The neurotoxin paralyzes muscles by inhibiting the release of acetylcholine.
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Old 09-26-2012
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One of my friends got this question on the real exam...

Waiting for official answer.
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Old 09-26-2012
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Its A.

Doesn't it prevent SNARE proteins somehow?
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Old 09-26-2012
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Quote:
Originally Posted by belindalimm View Post
A 42-year-old women comes to the doctor's office, aiming to find out a way to reduce the wrinkles on her face. She was previously a super model. Replying to the patient's request, the doctor recommends injection of botulinum toxin. Which of the following best explain the mechanism of the toxin?

A. Prevents motor neuron secretory vesicle fuse with neuronal membrane
B. Blocks nicotinic aceytlcholine receptors
C. Inhibits Ca2++ release from SR
D. Inhibits choline uptake into motor neurons

Would go with A
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Old 09-26-2012
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Default The answer is A

Botulinum toxin is a very potent exotoxin produced by Clostridium botulinum. The toxin functions to inhibit Ach release from neural terminals via interfering with the vesicle docking and emptying(which is the same meaning with preventing motor neuron secretory vesicle fuse with neuronal membrane).

Botulinum toxin has no function in choline uptake inhibition. Hemicholinium is responsible for that.

Is anybody here having idea of how the toxin helps reduce wrinkles?
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Old 09-26-2012
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Quote:
Originally Posted by belindalimm View Post
Botulinum toxin is a very potent exotoxin produced by Clostridium botulinum. The toxin functions to inhibit Ach release from neural terminals via interfering with the vesicle docking and emptying(which is the same meaning with preventing motor neuron secretory vesicle fuse with neuronal membrane).

Botulinum toxin has no function in choline uptake inhibition. Hemicholinium is responsible for that.

Is anybody here having idea of how the toxin helps reduce wrinkles?
I was going to ask same question. hahaha
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Old 09-26-2012
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Quote:
Originally Posted by belindalimm View Post
Botulinum toxin is a very potent exotoxin produced by Clostridium botulinum. The toxin functions to inhibit Ach release from neural terminals via interfering with the vesicle docking and emptying(which is the same meaning with preventing motor neuron secretory vesicle fuse with neuronal membrane).

Botulinum toxin has no function in choline uptake inhibition. Hemicholinium is responsible for that.

Is anybody here having idea of how the toxin helps reduce wrinkles?
well, my understanding is that wrinkles are caused by excessive facial muscle spasms which give rise to what they called it frown lines and forehead lines, And by injecting the toxin it will help to relieve these spasm and makes the face looks smooth . That is what cosmetic expert told ppl. But it make sense
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