Poxvirus Replication is Different - USMLE Forums
USMLE Forums Logo
USMLE Forums         Your Reliable USMLE Online Community     Members     Posts
Home
USMLE Articles
USMLE News
USMLE Polls
USMLE Books
USMLE Apps
Go Back   USMLE Forums > USMLE Step 1 Forum

USMLE Step 1 Forum USMLE Step 1 Discussion Forum: Let's talk about anything related to USMLE Step 1 exam


Reply
 
Thread Tools Search this Thread Display Modes
  #1  
Old 09-30-2012
USMLE Forums Guru
 
Steps History: 1+CK+CS
Posts: 307
Threads: 36
Thanked 127 Times in 61 Posts
Reputation: 137
Virus Poxvirus Replication is Different

I've a query regarding viral replication. As a general rule, most ds-DNA viruses replicate in the nucleus. An exception is Poxvirus which replicates in the cytoplasm. FA (and wiki) says that it's because the Pox virus carries its own DNA-dependant RNA polymerase to allow replication in the cytoplasm of the cell it infects. My confusion arises here: Why would an RNA polymerase allow Pox to carry out replication? Shouldn't it be a replication which is ds-DNA ---> ds-DNA? In which case, shouldn't it require a DNA-dependant DNA polymerase? Would appreciate the help if someone can answer this, thank you!
Reply With Quote Quick reply to this message



  #2  
Old 09-30-2012
USMLE Forums Master
 
Steps History: 1+CK+CS
Posts: 1,039
Threads: 189
Thanked 570 Times in 323 Posts
Reputation: 580
Default

it synthesizes RNA based on the information in its DNA (transcription-like process). right after RNA synthesis the protein synthesis can take place in the cytoplasm of the host cell.
Reply With Quote Quick reply to this message
The above post was thanked by:
dockhi (09-30-2012)
  #3  
Old 09-30-2012
USMLE Forums Guru
 
Steps History: 1+CK+CS
Posts: 307
Threads: 36
Thanked 127 Times in 61 Posts
Reputation: 137
Default

Makes sense! Not that we're prolly expected to know beyond this, but how is it making DNA then? Would a translation produce DNA polymerase? That's all I can think of!
Reply With Quote Quick reply to this message



Reply

Tags
Microbiology-

Quick Reply
Message:
Options

Register Now

In order to be able to post messages on the USMLE Forums forums, you must first register.
Please enter your desired user name, your email address and other required details in the form below.
User Name:
Password
Please enter a password for your user account. Note that passwords are case-sensitive.
Password:
Confirm Password:
Email Address
Please enter a valid email address for yourself.
Email Address:
Medical School
Choose "---" if you don't want to tell. AMG for US & Canadian medical schools. IMG for all other medical schools.
USMLE Steps History
What steps finished! Example: 1+CK+CS+3 = Passed Step 1, Step 2 CK, Step 2 CS, and Step 3.

Choose "---" if you don't want to tell.

Favorite USMLE Books
What USMLE books you really think are useful. Leave blank if you don't want to tell.
Location
Where you live. Leave blank if you don't want to tell.

Log-in

Human Verification

In order to verify that you are a human and not a spam bot, please enter the answer into the following box below based on the instructions contained in the graphic.



Thread Tools Search this Thread
Search this Thread:

Advanced Search
Display Modes


Similar Threads
Thread Thread Starter Forum Replies Last Post
Bacterial DNA Replication! alfjof USMLE Step 1 Forum 7 05-30-2012 12:50 PM
DNA Replication Which Is True? alfjof USMLE Step 1 Forum 6 05-30-2012 12:47 PM
Virus Replication lemontea88 USMLE Step 1 Forum 5 01-11-2011 10:34 PM
HIV Replication and pharmacology options Betro Sadek USMLE Step 1 Forum 4 10-19-2009 02:23 PM

RSS Feed
Find Us on Facebook
vBulletin Security provided by vBSecurity v2.2.2 (Pro) - vBulletin Mods & Addons Copyright © 2017 DragonByte Technologies Ltd.

USMLE® & other trade marks belong to their respective owners, read full disclaimer
USMLE Forums created under Creative Commons 3.0 License. (2009-2014)