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  #1  
Old 10-02-2012
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Heart Cardiac Tissue Amyloidosis!

An autopsy of a 83 yr who died at nursing home shows small amounts of Amyloid deposition in the heart. amyloid deposition is not seen in other organs. which of following subtypes is most likely present in the patient?
a) transthyretin
b) AA protein
c) AL protein
d) B2 Amyloid protein
e) B2microglobulin
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Old 10-02-2012
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transthyretin - senile one.
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Old 10-02-2012
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Default localised senile amyloid

....................................A
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Old 10-02-2012
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Default my answer :)

b)AA protein
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Quote:
Originally Posted by Casandra View Post
b)AA protein

why did you decided for it?
age above 80. Isolated in heart only. no history of chronic inflammatory state....
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Quote:
Originally Posted by Casandra View Post
b)AA protein
@casandra
why AA amyloid?is it not a systemic amyloid?and this pxt has no extra cadiac deposits
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Quote:
Originally Posted by blade View Post
@casandra
why AA amyloid?is it not a systemic amyloid?and this pxt has no extra cadiac deposits
I copied the wrong answer

it's a) transthyretin
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Quote:
Originally Posted by Casandra View Post
I copied the wrong answer

it's a) transthyretin

Yes
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Yes
thanks for being on-guard guys!
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thanks for being on-guard guys!
Thank you for making me to go to page 249 FA and recheking it
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Old 10-02-2012
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Quote:
Originally Posted by rupesh View Post
An autopsy of a 83 yr who died at nursing home shows small amounts of Amyloid deposition in the heart. amyloid deposition is not seen in other organs. which of following subtypes is most likely present in the patient?
a) transthyretin
b) AA protein
c) AL protein
d) B2 Amyloid protein
e) B2microglobulin
its a ......
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yup the ans is transthyretin aka pre albumin.....
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Old 10-02-2012
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Transthyretin amyloidosis is a disease caused by the abnormal accumulation of protein molecules in body tissues. These protein accumulations or “amyloid deposits” are made from a blood protein, transthyretin, which normally transports thyroid hormone and vitamin A to the body tissues. When an inherited defect in the transthyretin protein occurs, this abnormal form of transthyretin has the tendency to accumulate in tissues such as the heart, kidneys, nerves, and intestine. The presence of these deposits interferes with the normal functions of the organs, and as the deposits enlarge more tissue damage occurs and the disease (transthyretin amyloidosis) worsens.

Transthyretin is a normal blood protein. Its function is to carry thyroid hormone and vitamin A to tissues where they are needed for normal metabolism. Like all proteins transthyretin is made from the 20 different amino acids which are linked end to end to make large molecules. Each protein is identified by the arrangement of the amino acids in the protein chain and this arrangement is determined (coded) by a specific gene. In the case of transthyretin a single gene located on chromosome 18 codes for the amino acid alignment (sequence) which is characteristic of this protein and distinguishes it from all other proteins.
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transthyretin..

came across similar Q in UW... where the ans was deposition of atrial natriuretic peptide in elderly individual with LVH.


Atria produces ANP
Ventricles produce BNP
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