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Old 10-02-2012
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Drug Antihelminthics Mechanism of Action

A couple adopts a 6 yr old child from rural Guatemala and brings him for his first medical physical. They are worried about his nutritional status since he does not eat much food. He c/o abdominal discomfort after eating & points to the midepigastric region when asked. He is at the 25% for height & 10% for weight. On examination he has an erythematous maculopapular rash on his right foot that his parents say he scratches constantly. Stool studies are significant for hookworm ova.

What is the MOA used to treat this condition?

A. Inhibits DNA synthesis
B. Inhibits folic acid synthesis
C. Inhibits microtuble formation
D. Inhibits protein formation
E. Inhibits RNA synthesis
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Old 10-02-2012
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C. Inhibits microtuble formation
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Old 10-02-2012
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C. Inhibits microtuble formation
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Old 10-02-2012
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my asnwer ...........................C
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Old 10-02-2012
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i go with c blocks microtubule polymerization
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Old 10-02-2012
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Quote:
Originally Posted by blade View Post
A couple adopts a 6 yr old child from rural Guatemala and brings him for his first medical physical. They are worried about his nutritional status since he does not eat much food. He c/o abdominal discomfort after eating & points to the midepigastric region when asked. He is at the 25% for height & 10% for weight. On examination he has an erythematous maculopapular rash on his right foot that his parents say he scratches constantly. Stool studies are significant for hookworm ova.

What is the MOA used to treat this condition?

A. Inhibits DNA synthesis
B. Inhibits folic acid synthesis
C. Inhibits microtuble formation
D. Inhibits protein formation
E. Inhibits RNA synthesis
Would go with C
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Old 10-02-2012
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Default C is right

DOC for hookworm infection is albendazole or mebendazole.
They inhibit microtubule formation.

Other drugs with similar MOA;Griseofulvin,Colchicine,Vincristine,Vinblastin e,paclitaxel
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