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Old 10-05-2012
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Drug alpha 1 stimulation and dec renin release

please can any 1 explain how decrease alpha 1 stimulation causes decrease renin release
as alpha 1 is a stimulatory recptor ????
confused plz help
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Old 10-05-2012
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As afferent artrioles are under action of alpha 1 stimulation so pressure is maintained in these artrioles, any decress in this alpha 1 stimulation will lower the tension in afferent artriole which will be sensed by JGA and will release Renin.
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Old 10-05-2012
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Soorry i stated my question wrong kaplan says alpha 1 stimulation dec renin release plz sm1 telk how this happens
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i think its because renin release is directly under beta 1 effect.
it causes vasoconstriction via AT11 release.

so,alfa 1 stimulation also cause vasoconstriction therefore AT11 will not be needed hence no renin release
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Old 10-05-2012
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Think of it logically..Alpha 1 receptors cause systemic vasoconstriction which raises TPR. So it makes sense to inhibit renin release..otherwise you can end up with severe ischemia as a result of severe vasoconstriction. Thats how I remember it actually. Was mentioned in kaplan vids too.

While think of B1 stimulation in case of CHF. Where you have fluid overload so the heart tried to compensate (Inc HR and contracility), reduced RBF to kidneys activate renin release..etc.
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