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  #1  
Old 10-05-2012
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Immunology Toxoid reaction!

A healthy 19-year-old man receives a tetanus immunization booster prior to induction into the US Marines. Six hours later, he has pain and massive swelling at the site of injection. The following day, the skin breaks down, forming an ulcer at the site. Which of the following events plays a critical role in this reaction?
(A) Accumulation of mononuclear cells at the site of antigen injection
(B) Antigen capture by Langerhans cells in the epidermis
(C) Local fixation of complement by preformed circulating antibodies
(D) Local release of histamine
(E) Predominant synthesis of IgM antibodies
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  #2  
Old 10-05-2012
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arthrus reaction....type 3 hypersensitivity

thinking of b(as injection given in dermis) or c

i'll go with b) Ag capture by langerhans cells in epidermis

thanks
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  #3  
Old 10-05-2012
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I agree

if it is type 3 hypersensitivity .. then why do cells have a role???
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  #4  
Old 10-05-2012
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Quote:
Originally Posted by alice View Post
A healthy 19-year-old man receives a tetanus immunization booster prior to induction into the US Marines. Six hours later, he has pain and massive swelling at the site of injection. The following day, the skin breaks down, forming an ulcer at the site. Which of the following events plays a critical role in this reaction?
(A) Accumulation of mononuclear cells at the site of antigen injection
(B) Antigen capture by Langerhans cells in the epidermis
(C) Local fixation of complement by preformed circulating antibodies
(D) Local release of histamine
(E) Predominant synthesis of IgM antibodies
To me it looks arthus reaction
Normally shown by toxoid vaccines like tetanus and diphtheria vaccines. They act as antigen for antigen antibody complex.

According to these options I am confused with A and B.
Would go with
B. Antigen capture by Langerhans cells in the epidermis
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Old 10-05-2012
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Quote:
Originally Posted by alice View Post
if it is type 3 hypersensitivity .. then why do cells have a role???
yes, you are right..but i'm thinking of langerhans cells are antigen presenting cells...which helps further presenting the antigen and which lead to antibody isotype switching.....
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  #6  
Old 10-05-2012
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Default my answer :)

(C) Local fixation of complement by preformed circulating antibodies
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  #7  
Old 10-06-2012
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Default C

its arthus reaction... answer is C C C

as the patient is recieving booster dose so that means that pt previously has circulating antibodies in the body... booster toxoid antigen would trigger antigen antibody reaction which wud activate compliment system resulting in ac inflammation and ulcer formation.....
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  #8  
Old 10-06-2012
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its C........type 3 involves antigen-antibody and complement..................even FA has this........
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  #9  
Old 10-06-2012
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my guess is b antigen capture by langerans cells of epidermis..
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Old 10-06-2012
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Default its C

Quote:
Originally Posted by alice View Post
A healthy 19-year-old man receives a tetanus immunization booster prior to induction into the US Marines. Six hours later, he has pain and massive swelling at the site of injection. The following day, the skin breaks down, forming an ulcer at the site. Which of the following events plays a critical role in this reaction?
(A) Accumulation of mononuclear cells at the site of antigen injection
(B) Antigen capture by Langerhans cells in the epidermis
(C) Local fixation of complement by preformed circulating antibodies
(D) Local release of histamine
(E) Predominant synthesis of IgM antibodies


answer is C. booster dose means person already has circulation Ab against tetanus which fixes complement - Arthus reaction type III HSR
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  #11  
Old 10-06-2012
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I agree the answer !

CCCCCCC.....it is an arthus reaction .. immune complexes play a role...
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