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Old 10-06-2012
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Arrow Billy Step 1 Questions #8

A 54-year-old woman sees her physician after feeling a lump in her left breast. The physician palpates a firm, irregular mass in the lower outer quadrant just beneath the lateral margin of the areola. A mammogram shows a 2-cm density with
focal microcalcifications. Excisional biopsy shows intraductal and invasive components of a breast carcinoma. Immunohistochemical staining shows that the cells are positive for HER2/neu expression, but negative for estrogen receptor and progesterone receptor expression. Flow cytometry shows a small aneuploid peak and a low S-phase. When
combined with doxorubicin, which of the following drugs is most likely to be useful in treating this patient?

□ (A) Hydroxyurea
□ (B) Celecoxib
□ (C) Raloxifene
□ (D) Tamoxifen
□ (E) Trastuzumab
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Old 10-06-2012
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e) transtuzumab???
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Old 10-06-2012
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Obviously answer is (E) Trastazumab. Monoclonal antibody directed against HER2/Neu receptor which is expressed in this patient. Hormone therapy with antagonist is not applicable here as estrogen nd progesterone receptor revealed negative in d excised specimen.
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Old 10-06-2012
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Default E

Transuzumab ....
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Old 10-06-2012
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Default □ (E) Trastuzumab

(E) Trastuzumab- monoclonal antibody which interferes with HER2/neu.
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Old 10-06-2012
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transduzumab commonly known as HERceptin!!!
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Old 10-06-2012
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Correct Answer E

Yeah right
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