Polymyositis versus Dermatomyositis - USMLE Forums
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Old 10-06-2012
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Microscope Polymyositis versus Dermatomyositis

Polymyositis and dermatomyositis are linked to each other in many features...what is the following feature is present only in polymyositis in contrast to dermatomyositis..?

a) gottron's papules
b) heliotrope rash
c) perimysial inflammation
d) endomysial inflammation
e) antibody mediated damage
f) creatine kinase elevation
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Old 10-06-2012
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d) endomysial inflammation

i remember perimysial in dermatomyositis as perimysium is closer to skin
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Old 10-06-2012
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Default e) antibody mediated damage

Bro. u have to reframe this again.
It should be " present only in dermatomyositis in contrast to polymyositis.

PolyMyositis- T cell medicated (PMT)
Dermatomyositis- antibody mediated.
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Old 10-06-2012
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Quote:
Originally Posted by koolkiller88 View Post
Bro. u have to reframe this again.
It should be " present only in dermatomyositis in contrast to polymyositis.

PolyMyositis- T cell medicated (PMT)
Dermatomyositis- antibody mediated.
no dude...i think it's correctly phrased....
anyways let's see after i post my answer
thank you
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Old 10-06-2012
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i go with c perimyseal inflammation,,,,,
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Old 10-06-2012
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It is d) endomysial inflammation. I attached a histo with polymyositis, where you can see the endomysial inflamatory infiltrate and muscle fiber necrosis.
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Polymyositis versus Dermatomyositis-polymyositis.jpg  
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Old 10-06-2012
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Quote:
Originally Posted by Teona View Post
It is d) endomysial inflammation. I attached a histo with polymyositis, where you can see the endomysial inflamatory infiltrate and muscle fiber necrosis.
whew at last someone agreed thank you my friend
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Correct Answer D is right

yes, the correct answer is D) endomysial inflammation

polymyositis and dermatomyositis are inflammatory myopathies often confused with similar features here are some features

similar features------both cause proximal muscle weakness,elevated creatine kinase, anti Jo-1 antibody(60%)

here are some contrast features------

1) dermatomyositis------gottron's papules,heliotrope rash, malar rash(like sle),antibody mediated damage,perifascicular atrophy(perimysial inflammation-----as @beka-cts told remember it as skin lie towards the surface)

2) polymyositis------no papules,no rash, T-cell mediated damage(CD8-MHC-1------->lymphocytic infiltrate),endomysial inflammation,@ with gastric carcinoma usually
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Micrographs-, Musculoskeletal-, Pathology-, Step-1-Questions

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