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Old 10-07-2012
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Question Reversible and Irreversible Injury

Ya recently i did few questions in UW, NBME and Pretest which are continously asking some precise information about
Reversible and Irreversible Injury.
I checked in Rapid view but i think its not as good explained as i require.
In FA its given with good points but in very precise manner which still leave me with doubts.
So do anyone have more reliable information about this?
Yes i know i can search in google but i think there will be hell vast of information which will confuse me more. So If someone read this topic in any of preparatory books. Can you recommend that?
Thanks
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Old 10-07-2012
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i think that you should read robbins chapter I Morphologic Alterations in Cell Injury.
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According to severity of Cell injury we know that it can be either Reversible or Irreversible. When it is Reversible it is evident as Celllular Swelling,Fatty change
When it is Irreversible it is evident as either Necrosis and Apoptosis. So let's take a review of changes that occur in those spectrum>>>>>>Here it follows

Morphologic changes in Reversible Cell Injury:
A) Gross Change: Cellular Swelling (increased Na+>>>increases weight of the organ)

B)Microscopic Change
: Small clear vaucoles in cytoplasm (distended and pinched off segment of ER)

C)Ultra-structural Changes:

  • 1. Plasma membrane alterations: Blebbing,blunting and loss of microvilli.
  • 2. Mitochondrial Change: Swelling and appearance of small amorphous densities (due to phospholipid.
  • 3. Dilation of ER: Detachement of polysome.
  • 4. Nuclear Alterations: Disaggregation of granular and fibrillar elements.
Morphologic Changes in Irreversible Cell injury:

In Case of Necrosis
:

Light Microscopic Changes:
1. Increased Eosinophilia due to loss of RNA
2.Glassy homogenous appearance due to loss of glycogen.
3.Cytoplasm appears vaculated.

Nuclear changes:
Following sequeale of reactions occurs:
Pyknosis (nuclear shrinkage and increased basophilia)>>>>>>>>Karryorhexis (pyknotic nucleus undergoes fragmentation)>>>>>>>>Karyolysis (basophilia of chromatin fades gradually due to loss of DNA from enzymatic digestion by endonucleases)

In cases of Apoptosis:

1. Cell shrinkage.
2. Chromatin Condensation----most characteristic feature of apoptosis.
3. Formation of apoptotic bodies(membrane bound fragmented apoptotic cells)
4. Phagocytosis of apoptotic bodies usually by macrophages.

Hope it helps................
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