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Old 10-07-2012
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Question Celiac Disease Bone Pathology!

A 32 yr female presents with diarrhea, wt loss for years now presents with diffuse bone pain. the diarrhea improves on diet free in wheat; barley; rye. what is most likely seen on her serum serology
a) increase PTH; increase PO4 & Ca2+
b) increase PTH; decrease PO4 & DECREASE Ca 2+
c) increase PTH; decrease PO4 & INCREASE Ca 2+
d) decrease PTH; PO4 & Ca 2+
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Old 10-07-2012
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Might be C
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Old 10-07-2012
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My answer: B), because celiac disease-> malabsorption-> decreased vit D absorption -> decreased Ca2+ and PO4, which increases PTH
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Old 10-07-2012
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Default my answer B

decrease PO4 & DECREASE Ca 2+ due Hipovitaminosis D
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Old 10-07-2012
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Quote:
Originally Posted by rupesh View Post
A 32 yr female presents with diarrhea, wt loss for years now presents with diffuse bone pain. the diarrhea improves on diet free in wheat; barley; rye. what is most likely seen on her serum serology
a) increase PTH; increase PO4 & Ca2+
b) increase PTH; decrease PO4 & DECREASE Ca 2+
c) increase PTH; decrease PO4 & INCREASE Ca 2+
d) decrease PTH; PO4 & Ca 2+
I would go with C
Decreased reabsorption of phosphate and calcium from intestine. Cause increase in PTH which leads to osteoporosis. So there would be increase in Ca2+ with increase in ALP.


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Old 10-07-2012
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Default coeliac disease with bone pathology

Quote:
Originally Posted by koolkiller88 View Post
I would go with C
Decreased reabsorption of phosphate and calcium from intestine. Cause increase in PTH which leads to osteoporosis. So there would be increase in Ca2+ with increase in ALP.


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I would go with (B) decrese in Vit D abs -hypocalcemia and hypoposphatemia-PTH secretion
The increase in PTH will try to correct the hypocalcemia but wont end up causing hypercalcemia as once the calcium levels are normal the secretion of PTH will be decreased!
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Last edited by preeti617; 10-07-2012 at 08:50 PM. Reason: misspelt a word
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Old 10-07-2012
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Originally Posted by preeti617 View Post
I would go with (B) decrese in Vit D abs -hypocalcemia and hypoposphatemia-PTH secretion
The increase in PTH will try to correct the hypocalcemia but wont end up causing hypercalcemia as once the calcium levels are normal the secretion of PTH will be decreased!
Ya u r right. Just messed up simple stuff.
So it would be B.
PTH inc, Ca2+ dec, PO4- dec,


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Old 10-07-2012
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Default my answer :)

b) increase PTH; decrease PO4 & DECREASE Ca 2+
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Old 10-08-2012
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Correct Answer

celiac disease>>>decrease vit d>>>>decrease ca and po4 with compensatory rise in pth
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