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Old 10-09-2012
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Help Alkaline phosphatase in Hyperparathyroidism

Why is there an increase in the levels of alkaline phosphatase in osteitis fibrosis cystica?
As I understand there is an increase in ALP when there is an increase in osteoblast activity. In Primary Hyperparathyroidism there will be increase in bone resorption in response to PTH so why the increase in ALP?
Am I missing some imp concept?
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Old 10-09-2012
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PTH acts only on Osteoblasts to increase there activity>>> bone formation by matrix deposition n increased ALP

But Osteoblasts also secrete RANK-ligand n M-CSF which increase the osteoclastic activity leading to concurrent bone resorption, this process is v much increased in Primary HyperPTH
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The above post was thanked by:
jeniaz (10-29-2014), matxjos (11-24-2015)


Biochemistry-, Musculoskeletal-, Pathology-, Physiology-

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