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Old 08-18-2010
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Drug Use of calcium channel blocker in CHF

A 65 year old man with CHF & poorly controlled hypertension presents with new onset of anginal symptom during periods of exertion. His physician prescribes a calcium channel blocker for anginal prophylaxis & for his hypertension. Which of the following drugs is most likely to exacerbate this patients condition?

  • A. Amlodipine
  • B. Diltiazem
  • C. Verapamil
  • D. Feldopine
  • E. Nilvadipine
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Nilvadipine??
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B. Diltiazem contraindicated in CHF
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C. Verapamil also worsen CHF n cardiac blocks due to its negative ionotropic n dronotropic effects....
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OMG I need to review my pharmacology
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Old 08-19-2010
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Quote:
Originally Posted by khushboo View Post
C. Verapamil also worsen CHF n cardiac blocks due to its negative ionotropic n dronotropic effects....
Yes u r rite. Verapamil is contraindicated in CHF due to its negative ionotropic & dromotropic effects.
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Quote:
Originally Posted by step1an View Post
Yes u r rite. Verapamil is contraindicated in CHF due to its negative ionotropic & dromotropic effects.
Shouldn't a patient use drug to have -ve inotropic effect so that their cardiac muscle can decrease the O2 consumption?
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Quote:
Originally Posted by Brothersa View Post
Shouldn't a patient use drug to have -ve inotropic effect so that their cardiac muscle can decrease the O2 consumption?
Yes that would help prevent angina but it can worsen the CHF. Verapamil has a strong negative inotropic & dromotropic effects, so it would exacerbate the pt's heart failure.

As a general rule use of calcium channel blockers in CHF is reserved for patients who also have angina and/or hypertension. Amlodipine is commonly used in this regard.
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Quote:
Originally Posted by step1an View Post
Yes that would help prevent angina but it can worsen the CHF. Verapamil has a strong negative inotropic & dromotropic effects, so it would exacerbate the pt's heart failure.

As a general rule use of calcium channel blockers in CHF is reserved for patients who also have angina and/or hypertension. Amlodipine is commonly used in this regard.
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Correct Answer Ans is c..............

Quote:
Originally Posted by step1an View Post
A 65 year old man with CHF & poorly controlled hypertension presents with new onset of anginal symptom during periods of exertion. His physician prescribes a calcium channel blocker for anginal prophylaxis & for his hypertension. Which of the following drugs is most likely to exacerbate this patients condition?

  • A. Amlodipine
  • B. Diltiazem
  • C. Verapamil
  • D. Feldopine
  • E. Nilvadipine
Ans is C...............
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