FA in ODC says that CO decreases the oxygen binding capacity with a left shift in the oxyen -hemoglobin dissociation curve.Isn't that oposite an increase in the oxygen binding capacity causes the curve to shift to the left and CO increases the afinity of the unbound haemoglobin.PLEASE SOMEONE RESPOND!
As Hb has 4 pockets to bind O2, suppose CO binds to 2 pockets so it will affect the other 2 pockets to hold the already bound O2 tightly,it competes the new O2 to bind with Hb but prevents the already bound O2 to dissoaciate, so in the presence of CO the curve shifts left.
CO has 200 times more affinity for Hb than O2 for Hb, therefore decrease O2 binding capacity of Hb, decrease O2 saturation & decrease O2 content of blood ---> decrease O2 unloading to tissues(b'coz Hb holds on to remaining O2)----> left shift on ODC.
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