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Old 10-17-2012
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Heart Two High Yield Qs about Congenital Heart Disease

i think this question is direct and easy for you all...but it's high yield to know it...

Q) prostaglandins are used for.....?

a) ASD
b) PDA
c) TOF
D) VSD
E) TGA
F) TAPVC
G) CoA

Q) most commonly associated with fetal alcohol syndrome and 22q11 deletion respectively

A) TOF; TOF
B) VSD; VSD
C) ASD;TGA
D) TOF; Trunc. ARTERIOSUS(TA)
E) VSD; TGA
F) ASD; TOF
G) VSD; TA
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Old 10-17-2012
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Q1: prostaglandins are used to keep the PDA open in TGA ... And the most common anamoly in foetal alcohol syndrome is ASD and in 22q11 , it is TOF followed by interrupted aortic arch ..
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Post 1.e 2.g

the correct answers....are 1.E 2.G

1.it's important to know that how prsoataglandins influence the ductus arteriosus......normally after birth,first breath of the baby leads to decreased pulmonary vascular resistance,increased oxygen and decreased prostaglandins which closes ductus arteriosus........
so for closure of ductus arteriosus -------indomethacin is used...

TGA is due to failure of spiralisation of AP septum,which abnormally lead to opening of pulmonary valve in LV and systemic aorta in RV.....so any of the shunts must be needed for life(ASD,VSD,PDA).......mostly paediatricians use prostaglandins for patency of PDA....


2. most common congenital cardiac anomalies associated with fetal alcohol syndrome is VSD>ASD(due to cell migration inhibition )....
and most common cardiac anomalies associated with 22q11 deletion is-----TA=TOF....
and do also remember fetal alcohol syndrome is the most common cause of mental retardation in infants
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Old 10-17-2012
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Quote:
Originally Posted by venky2600 View Post
the correct answers....are 1.E 2.G

1.it's important to know that how prsoataglandins influence the ductus arteriosus......normally after birth,first breath of the baby leads to decreased pulmonary vascular resistance,increased oxygen and decreased prostaglandins which closes ductus arteriosus........
so for closure of ductus arteriosus -------indomethacin is used...

TGA is due to failure of spiralisation of AP septum,which abnormally lead to opening of pulmonary valve in LV and systemic aorta in RV.....so any of the shunts must be needed for life(ASD,VSD,PDA).......mostly paediatricians use prostaglandins for patency of PDA....


2. most common congenital cardiac anomalies associated with fetal alcohol syndrome is VSD>ASD(due to cell migration inhibition )....
and most common cardiac anomalies associated with 22q11 deletion is-----TA=TOF....
and do also remember fetal alcohol syndrome is the most common cause of mental retardation in infants

@venky - thanks for the questions
by TA do you mean tricuspid atresia?
thanks
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Quote:
Originally Posted by Casandra View Post
@venky - thanks for the questions
by TA do you mean tricuspid atresia?
thanks
your most welcome----it's truncus arteriosus(as i mentioned the name above in the question ,i abbreviated it)
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Originally Posted by venky2600 View Post
your most welcome----it's truncus arteriosus(as i mentioned the name above in the question ,i abbreviated it)
so why did you write TA=TOF?

edit: another question: could you please provide the source of info that the MC congenital heart disease in DiGeorge syndrome is TA? In this syndrome I read only about Tetrallogy of Fallot and interrupted aortic arch.
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Quote:
Originally Posted by Casandra View Post
so why did you write TA=TOF?
i mean both are eually prevalent in case of 22qll deletion....whereas in fetal alcohol--VSD>ASD...

given in F.A too in heart pathology section
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Quote:
Originally Posted by venky2600 View Post
i mean both are eually prevalent in case of 22qll deletion....whereas in fetal alcohol--VSD>ASD

I agree with VSD in alcohol fetal syndrome. I know nothing about TA in DiGeorge syndrome... so I would appreciate if you could provide the source of that information. thanks

edita: ok, I found it. thanks
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Quote:
Originally Posted by Casandra View Post
I agree with VSD in alcohol fetal syndrome. I know nothing about TA in DiGeorge syndrome... so I would appreciate if you could provide the source of that information. thanks

edita: ok, I found it. thanks
and also... from wiki

Up to 50% (varies in studies) of cases are associated with chromosome 22q11 deletions (DiGeorge Syndrome).

http://en.wikipedia.org/wiki/Persist...cus_arteriosus
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Old 10-18-2012
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Idea! Correction

Quote:
Originally Posted by venky2600 View Post
the correct answers....are 1.E 2.G

1.it's important to know that how prsoataglandins influence the ductus arteriosus......normally after birth,first breath of the baby leads to decreased pulmonary vascular resistance,increased oxygen and decreased prostaglandins which closes ductus arteriosus........
so for closure of ductus arteriosus -------indomethacin is used...

TGA is due to failure of spiralisation of AP septum,which abnormally lead to opening of pulmonary valve in LV and systemic aorta in RV.....so any of the shunts must be needed for life(ASD,VSD,PDA).......mostly paediatricians use prostaglandins for patency of PDA....


2. most common congenital cardiac anomalies associated with fetal alcohol syndrome is VSD>ASD(due to cell migration inhibition )....
and most common cardiac anomalies associated with 22q11 deletion is-----TA=TOF....
and do also remember fetal alcohol syndrome is the most common cause of mental retardation in infants
i wanna correct something here about what causes VSD and ASD
it's endocardial cushion defect

while neural crest migration results in TOF, TGA , and truncus arteriosus.
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