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Old 10-18-2012
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Drug Antiviral Drug Mechanism of Action

A 1 yr old male child has been presented to a physician with coughing and shortness of breath since a week ..on auscultation intermittent wheezes present with abnormal breath sounds. his temperature is above normal and his immunization schedule is improper..the causative agent is nonsegmented RNA virus...the physician prescribed an antiviral drug to treat it which has the mechanism of action similar to....?

a) palivizumab
b) azathioprine
c) lamivudine
d) streptomycin
e) mycophenolate
f) methysergide
g) etanercept
h) nalidixic acid....
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Old 10-18-2012
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A- Palivizumab.. for RSV?

Even though we use palivizumab to actually treat it, not a drug similar, so not sure?
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Old 10-18-2012
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BB...ribavirin inhibits nucleotide synthesis. azathioprine has similar MOA?
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Old 10-19-2012
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Correct Answer E is right

the correct answer is E) mycophenolate....

@blade----yes both acts on nucleotide synthesis......but mycophenolate is the most appropriate one...

looks like no one did like the question

the case presented here in the stem is a classic presentation of respiratory syncytial virus..which is a RNA virus that affects infants with cough and wheezes....
treatment options include-----ribavirin(antiviral----not effective at all now),palivizumab(fusion inhibitor---most widely used now) and also interferons...

antiviral used here is ribavirin..........ribavirin has 2 actions(one on RNA viruses and one on DNA viruses---)
1. RNA viruses action is pairing with uracil or cytosine and causing mutations in RNA dependant viruses(not Retro viruses)
2.DNA viruses action is inhibiting IMP(inosine monophosphate )dehydrogenase...by inhibiting no purine mono nucleotides can be formed....

Mycophenolate mofetil is the immunosuppressive prodrug that competitvely inhibits IMP dehydrogenase...it is used for transplants,SLE,behgets syndrome etc....

a) palivizumab----is a monoclonal antibody used for RSV
b) azathioprine----is an immunosuppressive agent that block purine synthesis(prodrug of 6-MP)
c) lamivudine-----it is a nucleoside reverse transcriptase inhibitor for HIV infection
d) streptomycin------it is an antibiotic acts by protein synthesis inhibition
f) methysergide------it is a serotonin receptor antagonist used for migraine----retroperitoneal fibrosis and pulmonary fibrosis are side effects
g) etanercept---it is a TNF decoy receptor antibody used for rheumatoid arthritis,crohn's
h) nalidixic acid.... ----it is a flouroquinolone antibiotic act by inhibitng DNA gyrase

it's only high yield to know the action of ribavirin on DNA viruses(IMP dehydrogenase inhibition)......side effects of ribavirin is hemolytic anemia
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Old 10-19-2012
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I wanted to but forgot pharmacology read it long baaccckk .. All the drugs sounded Greek and Latin to me !! Dint dare enough to guess . Nice question though
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Quote:
Originally Posted by alice View Post
I wanted to but forgot pharmacology read it long baaccckk .. All the drugs sounded Greek and Latin to me !! Dint dare enough to guess . Nice question though

haha..it happened to be many times before....goodluck
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