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Old 10-19-2012
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Virus Hepatitis Virus - Dane Particle

Dane particle.. Is it infectious or not ?? Kaplan says yes and U world says not .. Is it same as HBsAg ?? Can someone clear this ??
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Old 10-19-2012
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hey
i'm thinking dane particle is formed by HBsAg till now..

what i know is dane particle is 22nm in diameter.....and HBsAg forms it.......i think it comprises the virion associated particles...so infective

anyways...wait for some other explanations too.....
can you tell me the uworld q ID numbr

thanks
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Old 10-19-2012
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When I did u world I just noted down in my book That it is a noninfectious glycoprotein that forms 22 nm spheres and tubules .. Wiki says Dane particles are 42 nm .. I'm all confused ..
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Quote:
Originally Posted by alice View Post
When I did u world I just noted down in my book That it is a noninfectious glycoprotein that forms 22 nm spheres and tubules .. Wiki says Dane particles are 42 nm .. I'm all confused ..
ya wiki is true...and i'm wrong....

i googled it.......dane particle is 42nm consists of HBcAg,HBeAg and DNA polymerase...
and i think it's correct cause in f.a too in the diagram the whole virus particle is labelled as dane particle.....this might be helpful...

thanks for the question.....i got corrected now

so uworld is also correct regarding noninfectious 22nm particle

http://www.gpnotebook.co.uk/simplepa...?ID=-348848106

Nomenclature of hepatitis B


HBV


hepatitis B virus(complete infectiousvirion)

The 42 nm, double-shelled particle, originally called the Dane particle, thatconsists of a 7 nm thick outer shell and a 27 nm inner core. The core contains a small, circular, partially double-stranded DNA molecule and an endogenous DNApolymerase. This is the prototype agent for the family Hepadnaviridae.


HBsAg

hepatitis B surfaceantigen (also called envelope antigen)

The complex of antigenic determinants found on the surface of HBV and of 22 nm particles and tubular forms. It was formerly designatedAustralia (Au) antigen or hepatitis-associatedantigen (HAA).


HBcAg


hepatitis B coreantigen

The antigenic specificity associated with the 27 nm core of HBV.



HBeAg


hepatitis B e antigen

The antigenic determinant that is closely associated with the nucleocapsid of HBV. It also circulates as a soluble protein in serum.


Anti-HBs, anti-HBc, and anti-HBe


Antibody to HBsAg,HBcAg, and HBeAg

Specific antibodies that are produced in response to their respective antigenic determinants.

From: Hollinger FB, Liang TJ. Hepatitis B Virus. In: Knipe DM et al., eds. Fields Virology 4t ed.

took from http://www.who.int/csr/disease/hepat...en/index2.html
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Old 10-19-2012
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I don't understand about the U world being correct .. I'll try to give a gist .. Tell me if it is correct ..,HBsAg is non infectious 22nm... Where as Dane particle is the whole thing , 42nm infectious particle ... Right ??
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Thank you so much for the information .. Cleared it all
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Old 10-20-2012
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The complete hepatitis B virion is called the Dane particle. It is a DNA virus of the Hepadna family and consists of an outer envelope and core.
The core is formed in the hepatocyte nucleus. It contains:
  • partially double stranded circular DNA - there is a single stranded gap which is repaired by the DNA polymerase
  • DNA polymerase
  • core antigen - HBcAg
  • 'e' antigen - a protein sub-unit of the core - HbeAg
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