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Old 10-19-2012
koolkiller88's Avatar
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Bones Osteoid

Hey guys,
I always thought i understand this when i read
but when i do question i get lost.
Can anyone give me a brief picture about this-

Osteoid, osteoid matrix (is it same as bone matrix?)

wiki say "osteoid is unmineralized, organic portion of bone matrix.
but it also say defective mineralization of osteoid lead to osteomalacia/ rickets
So is i am getting crazy or there is really a basic concept involved which i am not aware of.
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  #2  
Old 10-25-2012
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Default dont be confused

Osteoid is the bone extracellular matrix which is formed by the multipotent mesenchymal cells (osteoblasts). It does not have any minerals like calcium or magnesium..they are all stored in the bony part. Osteoid basically consists of glycosaminoglycans and collagen type 1.
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Old 10-28-2012
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Quote:
Originally Posted by aniraiqbal View Post
Osteoid is the bone extracellular matrix which is formed by the multipotent mesenchymal cells (osteoblasts). It does not have any minerals like calcium or magnesium..they are all stored in the bony part. Osteoid basically consists of glycosaminoglycans and collagen type 1.
thanks for reply but then
defective mineralization of osteoid lead to osteomalacia/ rickets
What this mean?? or its just a poor generalization??
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Old 10-28-2012
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Default Osteoid

Quote:
Originally Posted by koolkiller88 View Post
thanks for reply but then
defective mineralization of osteoid lead to osteomalacia/ rickets
What this mean?? or its just a poor generalization??

Osteoid is like the foundation of bone. It is not yet mineralized with Calcium, once it does become mineralized it becomes bony cells. So in osteomalacia or rickets the problem is the osteoid layer is not becoming mineralized (calcified so to speak) and not becoming true bone.

Think of it like a house the Osteoid is the beams and the calcium is the actual walls, without the calcium you never actually can finish building the house.
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Histology-, Musculoskeletal-

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