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  #1  
Old 10-22-2012
billy's Avatar
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Arrow Billy Step 1 Questions # 44,45,46

** Which of the following drugs acts primarily
on an intracellular receptor?


(A) abciximab
(B) dexamethasone
(C) insulin
(D) propranolol
(E) salmeterol


** Which of the following drugs inhibit osteoclastic
activity more than osteoblastic activity
and have been beneficial in osteoporosis, hypercalcemia
of malignancy, and Paget disease?

(A) alendronate
(B) calcitonin
(C) fluoride
(D) parathyroid hormone
(E) vitamin D


** Serotonin (5-HT) is one of several mediators
of the signs and symptoms of carcinoid tumor.
When released from this neoplasm, most of the
manifestations of 5-HT are the result of activation
of the 5-HT2 receptor. These manifestations
are therefore likely to include which of the
following effects?

(A) bronchospasm
(B) constipation
(C) skeletal muscle weakness
(D) tachycardia
(E) ulceration of the stomach or duodenum
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  #2  
Old 10-22-2012
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will go with

1. B) dexamethasone----steroids act via nuclear receptors

2. A) alendronate-----bisphosphonates

3. A) bronchospasm----went by exclusion...either A or B.....as cyproheptadine(5-HT2 antagonist is used for excess GI stimulation) going with this....not sure

ya...i did blunder......carcinoid syndrome presents with diarrhea.......

thanks
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  #3  
Old 10-22-2012
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1.B
2. A
3
(A) bronchospasm
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  #4  
Old 10-22-2012
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1)intranuclear receptor dexamethasone
2)bisphosphonate>>alindronate
3)carcinoid syndr>>bronchospasm
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  #5  
Old 10-22-2012
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Quote:
Originally Posted by billy View Post
** Which of the following drugs acts primarily
on an intracellular receptor?


(A) abciximab
(B) dexamethasone
(C) insulin
(D) propranolol
(E) salmeterol


** Which of the following drugs inhibit osteoclastic
activity more than osteoblastic activity
and have been beneficial in osteoporosis, hypercalcemia
of malignancy, and Paget disease?

(A) alendronate
(B) calcitonin
(C) fluoride
(D) parathyroid hormone
(E) vitamin D


** Serotonin (5-HT) is one of several mediators
of the signs and symptoms of carcinoid tumor.
When released from this neoplasm, most of the
manifestations of 5-HT are the result of activation
of the 5-HT2 receptor. These manifestations
are therefore likely to include which of the
following effects?

(A) bronchospasm
(B) constipation
(C) skeletal muscle weakness
(D) tachycardia
(E) ulceration of the stomach or duodenum

1- B - dexamethasone (and endogenous steroids) work intracellularly
2- A - alendronate (DOC for Paget's) preferentially inhibits the action of osteoclasts at sites of high resorption.
3- A - typical signs of carcinoid syndrome = wheezing, diarrhea and flushing.
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  #6  
Old 10-22-2012
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1.b
2. A
3. A
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  #7  
Old 10-23-2012
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Correct Answer B , A and A are correct

(B) Dexamethasone, a corticosteroid, combines
with a cytoplasmic steroid receptor, enters the
nucleus, and alters gene expression. The other
agents listed (choices A, CE) act on membrane
receptors.


(A) Alendronate is a bisphosphonate, the class
of drugs that has proved most effective in the
treatment and prevention of osteoporosis. This
class of drug is also useful in the management
of hypercalcemia and certain neoplasms.
Calcitonin (choice B) has been shown to slow
bone loss in postmenopausal women and to
treat postoperative pancreatitis. Fluoride
(choice C) is used primarily in the prevention of
dental caries. Parathyroid hormone (choice D),
marketed as Forteo, is currently used in the
clinic to treat osteoporosis. Vitamin D (choice E)
has shown benefit in increasing bone deposition
in osteoporotic patients. However, choices BE
do not have clinical use in the treatment of
malignancy or Paget disease

(A) 5-HT2 receptors mediate smooth muscle
contraction and thus cause bronchospasm and
diarrhea, not constipation (choice B). Skeletal
muscle (choice C) and cardiac muscle (choice D)
are relatively insensitive to 5-HT. Peptic ulceration
(choice E) is not mediated in part by 5-HT;
the autacoid actually reduces acid secretion
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  #8  
Old 10-24-2012
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Quote:
Originally Posted by billy View Post
(B) Dexamethasone, a corticosteroid, combines
with a cytoplasmic steroid receptor, enters the
nucleus, and alters gene expression. The other
agents listed (choices A, CE) act on membrane
receptors.


(A) Alendronate is a bisphosphonate, the class
of drugs that has proved most effective in the
treatment and prevention of osteoporosis. This
class of drug is also useful in the management
of hypercalcemia and certain neoplasms.
Calcitonin (choice B) has been shown to slow
bone loss in postmenopausal women and to
treat postoperative pancreatitis. Fluoride
(choice C) is used primarily in the prevention of
dental caries. Parathyroid hormone (choice D),
marketed as Forteo, is currently used in the
clinic to treat osteoporosis. Vitamin D (choice E)
has shown benefit in increasing bone deposition
in osteoporotic patients. However, choices BE
do not have clinical use in the treatment of
malignancy or Paget disease

(A) 5-HT2 receptors mediate smooth muscle
contraction and thus cause bronchospasm and
diarrhea, not constipation (choice B). Skeletal
muscle (choice C) and cardiac muscle (choice D)
are relatively insensitive to 5-HT. Peptic ulceration
(choice E) is not mediated in part by 5-HT;
the autacoid actually reduces acid secretion
How does parathormone help in osteoporosis??
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