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Old 10-24-2012
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Biochemistry Hormone Sensitive Lipase versus Lipoprotein Lipase!

Hi
I'm a little confused. what's the difference between hormone sensitive lipase and lipoprotein lipase?
thanks!
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LPL is activated by insulin and it favors TG accumulation in adipose tissue whereas HSL is activated by stress hormones (glucagon etc) and causes lipid mobilization from stores
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Default HSL and lipoprotein Lipase

Hormone sensitive lipase breaks down triglyceride into fatty acid and glycerol during fasting under influence of increase epinephrine/cortisol or decrease insulin.
Lipoprotein lipase breakdown chylomicron/VLDL and involves in uptake of triglyceride into adipose tissues (Chyllomicron becomes remnant and VLDL becomes IDL). It recognize apo C-II on the surface of chylomicron/VLDL.
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