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Old 10-24-2012
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Question What autoantibodies?

A 3-year-old boy comes to the physician because of fever and erythema in his conjunctivae, oral mucosa, palms, and soles for the past week. Physical examination is significant for fever, enlarged cervical lymph nodes, and edema of the hands and feet. Although the precise cause of the patient's disease is unknown, it is speculated that autoantibodies may play a role. Based on the known structure that is primarily affected in the patient's disease, what autoantibodies are suspected to be associated with this condition?

A Anticentromere antibodies
B Anti-endothelial cell antibodies
C Antihistone antibodies
D Anti-IgG antibodies
E Antinuclear antibodies
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Old 10-24-2012
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Default kawasaki dx

DD.anti-IgG antibodies...just guessing
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Old 10-24-2012
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Default my answer B

my asnwer B....

A Anticentromere antibodies--> CREST

C Antihistone antibodies-->lupus related w/drugs
D Anti-IgG antibodies--> A.R
E Antinuclear antibodies---> Lupus
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Old 10-24-2012
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Default my answer :)

B Anti-endothelial cell antibodies - Kawasaki disease
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Old 10-24-2012
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agree with casandra

B) antiendothelial cell antibodies

thanks
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  #6  
Old 10-25-2012
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its Kawasaki disease also called mucocutanous lymph node disease.

anti-endothelial cell antibodies i guess.
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Old 10-25-2012
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Has to be B.. Kawasaki Disease
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Old 10-25-2012
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Quote:
Originally Posted by MedicalExaminer View Post
A 3-year-old boy comes to the physician because of fever and erythema in his conjunctivae, oral mucosa, palms, and soles for the past week. Physical examination is significant for fever, enlarged cervical lymph nodes, and edema of the hands and feet. Although the precise cause of the patient's disease is unknown, it is speculated that autoantibodies may play a role. Based on the known structure that is primarily affected in the patient's disease, what autoantibodies are suspected to be associated with this condition?

A Anticentromere antibodies
B Anti-endothelial cell antibodies
C Antihistone antibodies
D Anti-IgG antibodies
E Antinuclear antibodies
I would choose B) Anti endothelial cell antibodies, because the stem q describes a boy with Kawasaki which is a vasculitis.
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Old 10-25-2012
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Yes Kawasaki Disease
Anti-endothelial.......
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The correct answer is B. To answer this question, one must know that Kawasaki's syndrome (also referred to as mucocutaneous lymph node syndrome) is an arteritis that primarily affects medium- and small-sized arteries. Hence, it makes sense that there is evidence suggesting the formation of anti-endothelial cell (and anti–smooth muscle cell) autoantibodies in patients with this disease. The clinical manifestations of this disease include fever for more than 5 days, cervical lymphadenopathy, a skin rash (which often has desquamation, or shedding of the skin), and erythema of the conjunctivae, oral mucosa, palms, and soles. Eighty percent of patients are under the age of 4 years. Twenty percent of patients develop cardiovascular disease, including coronary artery vasculitis and coronary artery aneurysm.

Answer A is incorrect. Anticentromere antibodies, which are found in 90% of patients with the CREST variant of scleroderma, are not particularly associated with Kawasaki's syndrome.

Answer C is incorrect. Antihistone antibodies, which are found in over 95% of patients with drug-induced lupus erythematosus, are not particularly associated with Kawasaki's syndrome.

Answer D is incorrect. Anti-IgG (rheumatoid factor) is not particularly associated with Kawasaki's syndrome. Elevated levels of serum rheumatoid factor are present in 80% of patients with rheumatoid arthritis.

Answer E is incorrect. Antinuclear antibodies, which are present in over 95% of patients with systemic lupus erythematosus, are not particularly associated with Kawasaki's syndrome.
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