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Old 10-26-2012
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Default biochem

6 yr malewith vision problem;mental problems;die stroke.autopsy reveals massive thrombosis of cerebral artery and renal infarcts.suppliment of which of following could have prevented patients death?
a)tyrosine
b)thiamine
c)pyridoxine
d)methionine
e)vit k
f)vit c
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Old 10-26-2012
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Default CC...Vit B6

C...Homocystinuria
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Old 10-26-2012
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agree, its homocystinuria, so vit b6 should be the answer.
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Old 10-27-2012
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Correct Answer

yah the ans is homocysteinemia.......
but my question is why cant we supplement methionine?????
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Old 10-27-2012
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Default my answer :)

c)pyridoxine
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Old 10-27-2012
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Quote:
Originally Posted by rupesh View Post
yah the ans is homocysteinemia.......
but my question is why cant we supplement methionine?????
and would giving methionine give us?? it wouldn't push the metabolism of homocysteine in any direction.
methionine is a next step in homocysteine turnover/metabolism so supplying it wouldn't help. just take a look at the diagram with this pathway in KLN.
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Old 10-27-2012
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Quote:
Originally Posted by rupesh View Post
yah the ans is homocysteinemia.......
but my question is why cant we supplement methionine?????
Methionine transforms in S Adenosylmethionine (SAM) which transforms in S Adenosylhomocysteine that ends up in homocysteine. So if you give methionine you will worsen the homocysteinemia.
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