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  #1  
Old 10-29-2012
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Question Microfibrils versus Collagen

a 21 yr male comes to the physician routine physical examination. he is tall and thin; long thin finger and hyperextensible joint. he states he always been called double jointed. his defect is in
a) desmosome
b) collagen 3
c) collagen 1
d) microtubules
e) microfibrils
f) microfilaments
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Old 10-29-2012
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marfan

e)microfibrils
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e)Microfibrils
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Default my asnwer B

mmm for me the buzz word is hyperextensible joint so Ehlers-Danlos synd--->colagen 3 (found in vessels)
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Default my answer :)

b)collagen 3
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i think B) collagen 3

thanks for the question.... i have some confusion in it too..hope it clears with your explanation..
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My answer is e

hypermobile joints we can find in both ehlers-danlos (type iii collagen is most frequently affected or type i) or marfan's syndromes but long fingers and toes (arachnodactyly) -in marfan's syndrome while skin hyperelasticity -in ehlers-danlos syndrome.
Marfan's syndrome-is ad ,carried by the gene fbn1(chromosome 15) which encodes fibrilin-1.fibrilins are large extracellular matrix proteins associated with both elastic and non-elastic microfibrils
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Old 10-30-2012
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E.microfibril..tall ,thin-marfanoid habitus..hyperextensible joints:Marfan's
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Old 10-30-2012
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hyperextensible joint-
I would go with collage 3 (Ehlers-Danlos syn)
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Old 10-31-2012
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ans is Marfans syndrome>>>FIBRILLIN component of Elastin associated Microfibrils
Arachnodactyly+hyperextensible joints
it is so confused with EDS......
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Quote:
Originally Posted by rupesh View Post
ans is Marfans syndrome>>>FIBRILLIN component of Elastin associated Microfibrils
Arachnodactyly+hyperextensible joints
it is so confused with EDS......
is there any importance of double jointed point? mentioned in the question

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Quote:
Originally Posted by rupesh View Post
ans is Marfans syndrome>>>FIBRILLIN component of Elastin associated Microfibrils
Arachnodactyly+hyperextensible joints
it is so confused with EDS......
What is the source of the question?
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@fuser KAPTEST is the source.
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