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  #1  
Old 10-31-2012
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Question Prostate Cancer versus BPH

What is seen in prostate cancer in contrast to BPH?

a) increased total PSA
B) increased PSA unbound to alpha antichymotrypsin
c) increased PSA bound to alpha antichymotrypsin.
d) decreased total PSA
e) most common at age >50 yrs
F) decreased PSA bound to alpha antichymotrypsin
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  #2  
Old 10-31-2012
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Default my answer :)

c) increased PSA bound to alpha antichymotrypsin.
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  #3  
Old 11-01-2012
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my guess is c
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  #4  
Old 11-01-2012
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Default

As i know
PSA is a proteolytic enzyme and alpha antichymotrypsin (as name says) its an anti protease enzyme but never read its co-relation with PSA.
so my guess
a) increased total PSA
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  #5  
Old 11-01-2012
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Going with C :sorry:
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  #6  
Old 11-01-2012
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not 100% about alpha antichymotrypsin so im going to say

A)
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  #7  
Old 11-01-2012
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my answer is C'
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  #8  
Old 11-01-2012
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a) increased total PSA
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  #9  
Old 11-01-2012
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Correct Answer c is right

the correct answer is C) PSA bound to alpha antichymotrypsin increase...

PSA(normal-0-4ng/ml) is nonspecific diagnosis for prostate disorders,it is elevated in prostate cancer,BPH ,prostatitits etc....so researchers found the differences in PSA in different disorders..

PSA exist in 2 forms--->1) complexed form --->PSA specifically bound to alpha1 antichymotrypsin in blood.....
2) free form

in BPH and other prostate related disorders-----> increased total PSA(normal to slightly high) with proportionate increase in free PSA


in prostate cancer-------> increased total PSA with decreased fraction of free PSA(increase in complexed PSA).......


( F.A -2012 --mentioned them but without adding the concept of alpha1 antichymotrypsin into it.and not clear either...)

in both the disorders ---->PSA is elevated(high in prosate cancer) and both are presented at greater than 50 yrs of age...


hope it understands.....thanks
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  #10  
Old 11-01-2012
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Default Option A and C are they not saying the same thing?

@ vencky

What's the difference between Total PSA and PSA bound to alpha antichymotrypsin?

I think they are the same thing said in two different ways????
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Old 11-01-2012
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Quote:
Originally Posted by blade View Post
@ vencky

What's the difference between Total PSA and PSA bound to alpha antichymotrypsin?

I think they are the same thing said in two different ways????
no, they aren't the same thing buddy..

total PSA= complexed PSA(bound to alpha antichymotrypsin) + free form....

in prostate cancer, complexed form increases more...
in BPH, free form increases....

summary is that -----in both total PSA increases....(i asked in the stem contrasting feature not similar feature....which makes C as answer..)...if i asked abt similar feature then,A and E would have been the right ones

if you dont get it...refer to F.A 2012--551 pg....you will know well ,compare BPH and prostate ca. PSA phrases given(but it's not clearly given in f.a IMO)

i hope it clears your doubt well....thanks

Last edited by venky2600; 11-01-2012 at 11:40 AM.
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  #12  
Old 11-01-2012
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Default Thanx alot

So it's better put this way? @Vencky

BPH:increase Total PSA + increase Free PSA(major contributory factor)
Prostate cancer:Inc Total PSA + Inc Complexed PSA(major contributory factor)

God bless !
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  #13  
Old 11-01-2012
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Quote:
Originally Posted by blade View Post
So it's better put this way? @Vencky

BPH:increase Total PSA + increase Free PSA(major contributory factor)
Prostate cancer:Inc Total PSA + Inc Complexed PSA(major contributory factor)

God bless !
ya right...you got the point buddy!...

better annotate in F.A too(as F.A only mentions decreased free PSA in prostate ca ).......for future use....

Last edited by venky2600; 11-01-2012 at 07:50 PM.
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  #14  
Old 11-02-2012
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Default More about PSA............ @venky

Adding to these great informations, I would like to add the ideas of different PSA reportings................
1. Increased "free" PSA= "Free" from cancer
2. PSA doubling time (PDT)= Lesser the PDT, more aggressive the tumor.
3. PSA Velocity= Rate of change of PSA values with time............yearly PSA
velocity>0.75ng/ml increases likelihood of developing prostate cancer......
this is the test you can do when total PSA is normal...........
4. Prostate density= ratio between serum PSA and volume of Prostate gland,
more is the ratio, more likelihood of prostate cancer...............thank you.
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  #15  
Old 11-02-2012
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Quote:
Originally Posted by venky2600 View Post
ya right...you got the point buddy!...

better annotate in F.A too(as F.A only mentions decreased free PSA in prostate ca ).......for future use....
Adding to these great informations, I would like to add the ideas of different PSA reportings................
1. Increased "free" PSA= "Free" from cancer
2. PSA doubling time (PDT)= Lesser the PDT, more aggressive the tumor.
3. PSA Velocity= Rate of change of PSA values with time............yearly PSA
velocity>0.75ng/ml increases likelihood of developing prostate cancer......
this is the test you can do when total PSA is normal...........
4. Prostate density= ratio between serum PSA and volume of Prostate gland,
more is the ratio, more likelihood of prostate cancer...............thank you.
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