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Old 11-02-2012
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Immunology Alpha chain of IL2 Receptor

A defect in common gamma chain of IL-2 receptor is one of the pathogenesis in SCID. Which of the following functions as alpha chain of IL-2 receptor?

A. T-reg cell
B. TH17 cell
C. Naive B cell
D. LAK cell
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Old 11-02-2012
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No answers??
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Old 11-02-2012
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Quote:
Originally Posted by subbi View Post
No answers??

i have no idea......just guessing by exclusion

D.....(coz it differentiate from Th1 cell)

A) is for IL10
B) for IL17
c) naive B cell may be with Th2 cells(IL4,IL5)

thanks for immuno q's(i'm slightly poor at it....
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Old 11-03-2012
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D is not the answer.............
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Old 11-03-2012
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Originally Posted by subbi View Post
D is not the answer.............
then, what's the correct answer..?
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Old 11-03-2012
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No answers??
subbi ,since u started posting immuno questions..I have to go back to IMMUNOLOGY..thanks for the stimulus I think its time to re read
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Old 11-03-2012
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Originally Posted by trupti View Post
subbi ,since u started posting immuno questions..I have to go back to IMMUNOLOGY..thanks for the stimulus I think its time to re read
Thanx trupti for ur compliment..............here the correct answer is AA. T-reg cell which is CD25 +ve and functions as alpha chain of IL-2 receptor..............activated TH cells can also function as alpha chain of IL-2 receptor...........thanx.
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Old 11-03-2012
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Quote:
Originally Posted by subbi View Post
Thanx trupti for ur compliment..............here the correct answer is AA. T-reg cell which is CD25 +ve and functions as alpha chain of IL-2 receptor..............activated TH cells can also function as alpha chain of IL-2 receptor...........thanx.
Thanks for question,
But pardon me for my lack of knowledge but i didn't know that IL-2 is made of any alpha, gamma or beta chain.
and as i remember about T-reg cell these are regulatory cells produced to keep check on other T cell (kinda inhibitory effect).
and didn't understood your explanation. You mean T reg cells are part of IL-2 receptors. So this means T reg cells do there inhibitory effect by binding to IL-2 receptor to inhibit further differentiation of T helper cells?

Seems like a new information on way Can you clarify your explanation a little. Thanks
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Old 11-03-2012
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Default my answer A

SCID: 2 FORMS

1.- A.recesive: adenosin deaminase def
2.- Xlinked recesive: a defect in chains of IL2

IL2 perform an "autocrine"function inducing cloning from a T cell (CD4)--->memory T cells w/ the same function and immunological properties

so my answer is A
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Old 11-03-2012
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Quote:
Originally Posted by koolkiller88 View Post
Thanks for question,
But pardon me for my lack of knowledge but i didn't know that IL-2 is made of any alpha, gamma or beta chain.
and as i remember about T-reg cell these are regulatory cells produced to keep check on other T cell (kinda inhibitory effect).
and didn't understood your explanation. You mean T reg cells are part of IL-2 receptors. So this means T reg cells do there inhibitory effect by binding to IL-2 receptor to inhibit further differentiation of T helper cells?

Seems like a new information on way Can you clarify your explanation a little. Thanks
Dear pal, T-reg cells express CD25 and transcription factor Fox P3............they perform their inhibitory action by secreting IL-10 which is an inhibitory cytokine (inhibits overactive T cells, superantigens and and hence T-reg cells prevent autoimmunity)...............IL-10 is probably synthesized via Fox P3............but the CD25 portion is the alpha chain of IL-2 receptor..........hope this helps.
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