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  #1  
Old 11-03-2012
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Question Non-membrane Associated Eukaryotic Protein!

Eukaryotic protein that exist as non-membrane associated, nonglycosyalted, disulfide link dimer in the mature form are generally form in which of follwing?
A Cytoplasm
B Extracellular space
C Mitochondrial space
D Nuclear matrix
E Nuclear pore
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The above post was thanked by:
preeti617 (11-03-2012), subbi (11-03-2012)



  #2  
Old 11-03-2012
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Default my answer :)

B Extracellular space
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Old 11-03-2012
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Default My Guess

I am thinking B Extracellular Space as well sounds like an Immunoglobulin to me: non-membrane associated, nonglycosyalted, disulfide link dimer
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Old 11-03-2012
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Default AA

AA.beta cells cytoplasm.......sounds like Insulin to me ??
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Old 11-03-2012
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also think it as A) cytoplasm

thanks
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Old 11-03-2012
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Quote:
Originally Posted by medhelp View Post
Eukaryotic protein that exist as non-membrane associated, nonglycosyalted, disulfide link dimer in the mature form are generally form in which of follwing?
A Cytoplasm
B Extracellular space
C Mitochondrial space
D Nuclear matrix
E Nuclear pore
This is IgA in my sense................it is formed in the cytoplasm and found in the extracellular space........so answer is AA.......
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Old 11-03-2012
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disulfide link dimer-->cysteine-->so it has tertiary structure (Ig)
but in the Qs point out "nonglycosyalted", i think that O-linked and N-linked glicosilation is necesary for postranslational modifications in Ig which forms in cyoplasma and then appear in extracelular space

just guessing my answer A
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Old 11-03-2012
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A disulphide link dimer is present as tyrosine kinase receptor
Quote:
Originally Posted by Fuser00 View Post
disulfide link dimer-->cysteine-->so it has tertiary structure (Ig)
but in the Qs point out "nonglycosyalted", i think that O-linked and N-linked glicosilation is necesary for postranslational modifications in Ig which forms in cyoplasma and then appear in extracelular space

just guessing my answer A
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Old 11-04-2012
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Quote:
Originally Posted by preeti617 View Post
A disulphide link dimer is present as tyrosine kinase receptor
yep is insuline receptor , my doub is about glicozilation of protein menbranes(for example lack of glycozilation of CFTRreceptor-->cystic fibrosis , i found this "the insulin receptor contains O-linked oligosaccharides on the NH2-terminal tryptic peptide of the beta-subunit, and these O-linked oligosaccharides are not necessary to the binding or autophosphorylation function of the receptor."

source:http://www.ncbi.nlm.nih.gov/pubmed/1991570

and the Qs point out "non-membrane associated, nonglycosyalted"

waiting the answer
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Old 11-05-2012
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Quote:
Originally Posted by Fuser00 View Post
yep is insuline receptor , my doub is about glicozilation of protein menbranes(for example lack of glycozilation of CFTRreceptor-->cystic fibrosis , i found this "the insulin receptor contains O-linked oligosaccharides on the NH2-terminal tryptic peptide of the beta-subunit, and these O-linked oligosaccharides are not necessary to the binding or autophosphorylation function of the receptor."

source:http://www.ncbi.nlm.nih.gov/pubmed/1991570

and the Qs point out "non-membrane associated, nonglycosyalted"

waiting the answer
Ans B extracellular space
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Old 11-05-2012
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@medhelp...................could you please explain what type of protein it is??..............thought of immunoglobulin A but I think i got wrong..............is it insulin receptor::is insulin receptor a dimer??.
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Old 11-05-2012
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Quote:
Originally Posted by subbi View Post
@medhelp...................could you please explain what type of protein it is??..............thought of immunoglobulin A but I think i got wrong..............is it insulin receptor::is insulin receptor a dimer??.
Sorry, as I don't know I ask the forum
Here is the link i found
http://www.prep4usmle.com/forum/thread/30082/
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  #13  
Old 11-06-2012
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Quote:
Originally Posted by medhelp View Post
Eukaryotic protein that exist as non-membrane associated, nonglycosyalted, disulfide link dimer in the mature form are generally form in which of follwing?
A Cytoplasm
B Extracellular space
C Mitochondrial space
D Nuclear matrix
E Nuclear pore
But in the other page the post of the qs: glycosilated instead nonglycosilated
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Old 11-06-2012
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Default b

is it extracellular space
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