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  #1  
Old 11-03-2012
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Immunology Graft versus Host Disease Immunology

Lifelong immunosuppressive therapy has decreased lots of requirements for tissue typing during transplantation. These therapies are used to combat rejection issues. Which of the following mediates host-versus-graft disease?
A. CD4+ T cells
B. CD8+ T cells
C. Macrophages
D. LAK cells
E. Antibodies and complement
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  #2  
Old 11-03-2012
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A CD4 T cells
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Default my answer :)

B. CD8+ T cells
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This question looks simple dear frens!!..........but it really got me in a spinning trouble..........please read the question carefully and give your best opinions............thank you.
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Old 11-04-2012
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Default The last question!!

Don't worry frens, this is the last question from immunology.............lol........will soon start on microbiology.
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Old 11-04-2012
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Quote:
Originally Posted by subbi View Post
Don't worry frens, this is the last question from immunology.............lol........will soon start on microbiology.
thanks for the qs! before you move on to micro can you please post the answer?
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Quote:
Originally Posted by subbi View Post
Don't worry frens, this is the last question from immunology.............lol........will soon start on microbiology.
thanks for the questions @subbi-----------from your questions i degraded from above avg. to below avg..(just kidding)........those are very scary----....let's battle in micro

thanks.
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Post forgot to answer

B) CD8+T cells........i think

thanks
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Quote:
Originally Posted by subbi View Post
This question looks simple dear frens!!..........but it really got me in a spinning trouble..........please read the question carefully and give your best opinions............thank you.
then, is it macrophage????........

but CD8 seems the appropriate one still...........
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Old 11-04-2012
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agree on B
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Default Concusionless!!!

Quote:
Originally Posted by venky2600 View Post
then, is it macrophage????........

but CD8 seems the appropriate one still...........
Yes, Venky you're right, thank you everyone for your answers, it's the CTL's that are mediating rejection of graft.............answer is CD8+ T cells............
Please conquer my queries frens:

As I stated earlier, this question really spun me...............LAK cells are Lymphokine-Activated Killer Cells which are in vitro stmulated NK cells that have increased capacity of killing..................now Kaplan mentions that (Pg. 179, explanation to answer 2) Lak cells are believed to be involved in the rejection of bone marrow transplants by the recipient k/a host-versus-graft disease, not graft-versus-host disease....................
On the other hand, LAK cells
suppress generation of allospecific cytotoxic T cells............

please refer to: http://www.ncbi.nlm.nih.gov/pubmed/1370206 ............according to kaplan LAK cells should be the answer but ............please share...............thank you all so much.......


By the way, this is last September's exam question where my fren put the answer CD8+ cells but I'm still not satisfied............
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Quote:
Originally Posted by subbi View Post
Yes, Venky you're right, thank you everyone for your answers, it's the CTL's that are mediating rejection of graft.............answer is CD8+ T cells............
Please conquer my queries frens:

As I stated earlier, this question really spun me...............LAK cells are Lymphokine-Activated Killer Cells which are in vitro stmulated NK cells that have increased capacity of killing..................now Kaplan mentions that (Pg. 179, explanation to answer 2) Lak cells are believed to be involved in the rejection of bone marrow transplants by the recipient k/a host-versus-graft disease, not graft-versus-host disease....................
On the other hand, LAK cells
suppress generation of allospecific cytotoxic T cells............

please refer to: http://www.ncbi.nlm.nih.gov/pubmed/1370206 ............according to kaplan LAK cells should be the answer but ............please share...............thank you all so much.......


By the way, this is last September's exam question where my fren put the answer CD8+ cells but I'm still not satisfied............
thanks for your explanation...i think you confused me little bit from your earlier post.....that's the reason i thought of macrophage for a second........if it isn't i would directly go with CD8+T cells...........this is my approcah to this q(it may vary from person to person)...
the 1st sentence in q. says..immunosuppressive agents used to decrease requirement of tissue typing------generally immunosuppressives during transplants are used to prevent acute rejection(host vs graft) which occurs in weeks to months after transplant,which damage is mediated by CTL's(CD8+T) leading to intense lymphocytic infiltrate .....this is the way i answered it(it may be wrong,but this is my approach..)

thanks for your question..
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Quote:
Originally Posted by venky2600 View Post
thanks for your explanation...i think you confused me little bit from your earlier post.....that's the reason i thought of macrophage for a second........if it isn't i would directly go with CD8+T cells...........this is my approcah to this q(it may vary from person to person)...
the 1st sentence in q. says..immunosuppressive agents used to decrease requirement of tissue typing------generally immunosuppressives during transplants are used to prevent acute rejection(host vs graft) which occurs in weeks to months after transplant,which damage is mediated by CTL's(CD8+T) leading to intense lymphocytic infiltrate .....this is the way i answered it(it may be wrong,but this is my approach..)

thanks for your question..

You're welcome fren!................but kaplan tends to show differences between GVHD and Host-Vs-Graft Disease by linking these LAK cells, the above article is very nicely explaining the role of LAK cells.......quite contradictory...............lol...............bett er to forget these types of question.............lol...............I think i'll post clear-cut ones next time, sorry.
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Quote:
Originally Posted by subbi View Post
You're welcome fren!................but kaplan tends to show differences between GVHD and Host-Vs-Graft Disease by linking these LAK cells, the above article is very nicely explaining the role of LAK cells.......quite contradictory...............lol...............bett er to forget these types of question.............lol...............I think i'll post clear-cut ones next time, sorry.
hey dont get wrong dude......the question is clear cut IMO....it's the options looks contradictory..every question will have the similar contradictoy options,from which we have to choose the appropriate one......ya the article seems quite promising,but some explanations need to be well published and understandable to all, until then the options which already given in our books to be followed IMO(i answered it according to F.A)....
your q's are good to improve ourselves(that's the reason everyone answering them)...dont get it wrong......
anyways i posted only my point of view...everyone will have their own approaches dude.......so dont worry abt your q's,they are good and do post them

Last edited by venky2600; 11-04-2012 at 04:40 PM.
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Old 11-04-2012
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Definitely CD8

CD8 T-cells are responsible for recognizing self
CD4 T-cells on the other hand are dependent on APC's. APC's are never involved with transplant rejections.

However with the cases of Hyperacute rejections which occurs immediately after a transplant, it is antibody mediated due to preformed anti-donor antibodies. Example - Our Blood Types.
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