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  #1  
Old 11-04-2012
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Immunology GM-CSF, TNF-alpha, and IL-2

A women with advanced metastatic breast cancer undergoes a radical mastectomy, followed by irradiation and chemotherapy. After a 2-years remission, a metastatic focus appears, and she enrolls in an experimental treatment protocol. In it a sample of her aspirated bone marrow is treated with GM-CSF, TNF-alpha, and IL-2, then pulsed with membrane fragments of her tumor cells and re-infused. Which of the following cell subpopulations is the most directly targeted by this treatment?

A) B lymphocytes
B) CTL
C) NK cells
D) TH1
E)TH2

Last edited by aOryx; 11-04-2012 at 10:43 AM.
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Old 11-04-2012
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i think it's D) TH1

thanks
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explain... IL2 will stimulate proliferation of CTL right?? and if it was for the changed MHC1 CTL will be the one to deal with it
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Quote:
Originally Posted by aOryx View Post
explain... IL2 will stimulate proliferation of CTL right??
yes, IL2 will stimulate CTL.....and also TNF alpha and GM-CSF have to deal more with macrophages(which are stimulated by IFN gamma)

IFN gamma and IL2 are differentiated from TH1 ,so it seemed as the most appropriate one......i may not be true though
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Originally Posted by venky2600 View Post
yes, IL2 will stimulate CTL.....and also TNF alpha and GM-CSF have to deal more with macrophages(which are stimulated by IFN gamma)

IFN gamma and IL2 are differentiated from TH1 ,so it seemed as the most appropriate one......i may not be true though
kaplans answer is TH1 too i dont get it :/
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Quote:
Originally Posted by aOryx View Post
kaplans answer is TH1 too i dont get it :/
yes, becoz...here the pt. has problem with both CTL(IL2) and macrophages(GM-CSF and TNF alpha)------so best way to treat is to target the TH1 which is the major differentiator for it.......it's the TH1 that helps in activation of CTL's by producing IL2 ...

hope it clears..thanks

Last edited by venky2600; 11-04-2012 at 11:05 AM.
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Old 11-04-2012
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Quote:
Originally Posted by aOryx View Post
A women with advanced metastatic breast cancer undergoes a radical mastectomy, followed by irradiation and chemotherapy.After a 2-years remission, a metastatic focus appears, and she enrolls in an experimental treatment protocol. In it a sample of her aspirated bone marrow is treated with GM-CSF, TNF-alpha, and IL-2, then pulsed with membrane fragments of her tumor cells and reinfused. Which of the following cell subpopulations is the most directly targeted by this treatment? A) B lymphocytes B) CTL C) NK cells D) TH1 E)TH2
Is it C) Nk cell. to kill cancer cells
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its TH1 cells
had to read an article about it
GM-CSF will increase dendritic cells (APC) will load MHC2 with the pulsed fragments
which will present it to TH1 cell and IL2 will increase proliferation
and apparently TGF-B will modulate the immune response

edit:://thanks every1

Last edited by aOryx; 11-04-2012 at 11:35 AM.
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i still dont get it. can someone plz explain it to me in detail. i also think that the answer should be CTLs. as they would b stimulated by IL-2

thanks in advance
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