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  #1  
Old 11-05-2012
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Bacteria Bacteria causing Diarrhea

A bacteria was being studied in European countries regarding its effect in the human gut. It was found that the bacteria produces a toxin which increases cAMP concentration in the gut altering the CFTR protein. Consequently it caused diarrhea which was of non-inflammatory type, and its incidence was increasing in people traveling to Mexico. However the organism was not oxidase +ve. Which of the following drugs, if regularly taken, increases the incidence of diarrhea caused by this organism?
A. Thiazide diuretics
B. H2 Blockers
C. NSAIDS
D. Insulin
E. No drug is associated with this type of scenario
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  #2  
Old 11-05-2012
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Default Nsaids

Organism- heat labile ETEC (Even kids know)
but answer i don't know
guess NSAIDS
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Old 11-05-2012
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Default B

I guess its H2 blockers.
Against vibrio cholera stomach acid is the main defense mechanism that would be lost by using these drugs.
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Old 11-05-2012
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guessing B) H2 blockers

V.cholerae...........(also thinking of E...)

THANKS
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Old 11-05-2012
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Vibrio is oxidase positive .. Isn't it ??
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Old 11-05-2012
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Default my answer :)

B. H2 Blockers - vibrio cholera can be stopped by gastric acidity
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Old 11-05-2012
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Quote:
Originally Posted by Casandra View Post
B. H2 Blockers - vibrio cholera can be stopped by gastric acidity
I guess you missed the part that says it's not oxidase positive?
No idea though
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Quote:
Originally Posted by alice View Post
Vibrio is oxidase positive .. Isn't it ??
yes indeed thanks for reminding....so i think now diagnosis is ETEC......but the answer..may be E i guess now
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Old 11-05-2012
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Quote:
Originally Posted by Timmi View Post
I guess its H2 blokcers.
Against vibrio cholera stomach acid is the main defence mechanism that wud be lost by using these drugs.

Hey guys, question says "not oxidase +ve".................is vibrio cholerae oxidase -ve??
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Old 11-05-2012
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Quote:
Originally Posted by chux View Post
I guess you missed the part that says it's not oxidase positive?
No idea though
yeah, I did. thanks!
so it's E.coli then. ETEC- travelers diarrhea.
my choice is still B) though
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I also think that its ETEC(HEAT LABILE TOXIN)-is It A)THIAZIDE DIURETIC_hypercalcemia???cant explain though..
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Old 11-05-2012
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Correct Answer BB is correct!!

Many of you would be correct in exam, though diagnosis was a bit shaking..............lol...............you're right frens, this is a case of traveller's diarrhoea................the symptoms in this case is directly proportional to the number of ingested organisms which reach the intestine alive. Hence, the risk of diarrheal diseases increases with the factors enhancing the ability of bacteria to survive ingestion (alkaline pH) and transit to the intestine..........common factors are H2 blockers, PPIs and prior ulcer surgery................
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Old 11-06-2012
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Question q

isnt H2 Receptor Gs coupled how inhibition oF H2 receptor causes Diarrhoea
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Quote:
Originally Posted by rupesh View Post
isnt H2 Receptor Gs coupled how inhibition oF H2 receptor causes Diarrhoea
See above explanation please............thanx.
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