Autoantibody against the skin! - USMLE Forums
USMLE Forums Logo
USMLE Forums         Your Reliable USMLE Online Community     Members     Posts
Home
USMLE Articles
USMLE News
USMLE Polls
USMLE Books
USMLE Apps
Go Back   USMLE Forums > USMLE Step 1 Forum

USMLE Step 1 Forum USMLE Step 1 Discussion Forum: Let's talk about anything related to USMLE Step 1 exam


Reply
 
Thread Tools Search this Thread Display Modes
  #1  
Old 11-05-2012
USMLE Forums Addict
 
Steps History: 1+CK+CS
Posts: 106
Threads: 35
Thanked 17 Times in 10 Posts
Reputation: 27
Skin Autoantibody against the skin!

A 62 yr old man develops numerous superficial blisters over scalp, face, groin and trunk. New lesion develop over area subjected to minimal trauma. Biopsy of one of lesion show intraepidermal blister with suprabasal acantholysis. Serologic studies likely to show an autoantibody directed against which of following.
A Anchoring filament
B Basement membrane protein
C Desmosomal protein
D Hemidesmosomal protein
E Integrin
Reply With Quote Quick reply to this message
The above post was thanked by:
Kanishk (11-06-2012), symport (11-06-2012), usmlemydream (11-05-2012)



  #2  
Old 11-05-2012
chux's Avatar
USMLE Forums Addict
 
Steps History: ---
Posts: 110
Threads: 4
Thanked 32 Times in 28 Posts
Reputation: 42
Send a message via AIM to chux
Default CC

P.vulgaris ............
__________________
focus
Reply With Quote Quick reply to this message
  #3  
Old 11-05-2012
USMLE Forums Addict
 
Steps History: Not yet
Posts: 110
Threads: 14
Thanked 64 Times in 33 Posts
Reputation: 74
Default

I think Pemphigus vulgaris...............IgG against desmosomal proteins.............I go with CC.
Reply With Quote Quick reply to this message
 
  #4  
Old 11-05-2012
USMLE Forums Guru
 
Steps History: 1 + CS
Posts: 303
Threads: 57
Thanked 106 Times in 67 Posts
Reputation: 116
Send a message via Skype™ to usmlemydream
Default

C...suprabasal bullae (vesicles) seen in PV
and subepidermal vesicles seen in bullous phemphigoid
__________________
the sky is not my limit....I am
Reply With Quote Quick reply to this message
  #5  
Old 11-05-2012
venky2600's Avatar
USMLE Forums Master
 
Steps History: 1+CK+CS+3
Posts: 1,186
Threads: 119
Thanked 822 Times in 434 Posts
Reputation: 832
Send a message via Yahoo to venky2600
Post

C) desmosomal pr.

thanks
Reply With Quote Quick reply to this message
  #6  
Old 11-06-2012
rupesh's Avatar
USMLE Forums Guru
 
Steps History: 1 + CS
Posts: 386
Threads: 71
Thanked 193 Times in 109 Posts
Reputation: 203
Send a message via AIM to rupesh
Default c

pemphigus vulgaris>>>>desmosome
Reply With Quote Quick reply to this message
  #7  
Old 11-06-2012
USMLE Forums Guru
 
Steps History: 1+CK+CS
Posts: 307
Threads: 36
Thanked 127 Times in 61 Posts
Reputation: 137
Default

"New lesion develop over area subjected to minimal trauma." Positive nikolsky's sign --> Pemphigus Vulgaris.
Reply With Quote Quick reply to this message
  #8  
Old 11-06-2012
USMLE Forums Scout
 
Steps History: Not yet
Posts: 23
Threads: 1
Thanked 1 Time in 1 Post
Reputation: 11
Default anser is C

Quote:
Originally Posted by dockhi View Post
"New lesion develop over area subjected to minimal trauma." Positive nikolsky's sign --> Pemphigus Vulgaris.
Yes, PV (desmosomas)
Reply With Quote Quick reply to this message
  #9  
Old 11-06-2012
USMLE Forums Addict
 
Steps History: 1+CK+CS
Posts: 109
Threads: 2
Thanked 41 Times in 34 Posts
Reputation: 51
Default

The answer is (C). Phempgus Vulgaruis (i think i butchered the naming, lol)

Anyway
the buzz word here is "Acantholysis" and its AB to Desmosome



the other one is Bullous "burrow" Phemgoid which is non-Acantholysis with AB to Hemi-desmosome
__________________
"Be Water, my friend."
Reply With Quote Quick reply to this message
  #10  
Old 11-06-2012
USMLE Forums Scout
 
Steps History: Not yet
Posts: 24
Threads: 2
Thanked 4 Times in 4 Posts
Reputation: 14
Default

my answer is 'C
Reply With Quote Quick reply to this message
  #11  
Old 11-06-2012
symport's Avatar
USMLE Forums Newbie
 
Steps History: Not yet
Posts: 5
Threads: 0
Thanked 0 Times in 0 Posts
Reputation: 10
Default

yes i absolutely go with all the others above in agreeing that the answer is definitely 'C'.
Reply With Quote Quick reply to this message
  #12  
Old 11-07-2012
Janakpriya's Avatar
USMLE Forums Addict
 
Steps History: Step 1 Only
Posts: 101
Threads: 9
Thanked 47 Times in 30 Posts
Reputation: 57
Send a message via Skype™ to Janakpriya
Default

Yes.. Suprabasal in pemphigus vulgaris. Nikolsky sign positive..ab against desmosomes
__________________

To view links or images in signatures your post count must be 10 or greater. You currently have 0 posts.
Reply With Quote Quick reply to this message



Reply

Tags
Pathology-, Skin-, Step-1-Questions

Quick Reply
Message:
Options

Register Now

In order to be able to post messages on the USMLE Forums forums, you must first register.
Please enter your desired user name, your email address and other required details in the form below.
User Name:
Password
Please enter a password for your user account. Note that passwords are case-sensitive.
Password:
Confirm Password:
Email Address
Please enter a valid email address for yourself.
Email Address:
Medical School
Choose "---" if you don't want to tell. AMG for US & Canadian medical schools. IMG for all other medical schools.
USMLE Steps History
What steps finished! Example: 1+CK+CS+3 = Passed Step 1, Step 2 CK, Step 2 CS, and Step 3.

Choose "---" if you don't want to tell.

Favorite USMLE Books
What USMLE books you really think are useful. Leave blank if you don't want to tell.
Location
Where you live. Leave blank if you don't want to tell.

Log-in

Human Verification

In order to verify that you are a human and not a spam bot, please enter the answer into the following box below based on the instructions contained in the graphic.



Thread Tools Search this Thread
Search this Thread:

Advanced Search
Display Modes


Similar Threads
Thread Thread Starter Forum Replies Last Post
Residency in skin in usa after MD skin in India parshva24 IMG Residency Match Forum 0 08-26-2012 11:44 PM
Skin ca scopusmount USMLE Step 1 Forum 4 01-19-2012 11:00 AM
skin lesion scopusmount USMLE Step 1 Forum 5 11-03-2011 09:18 AM
Six Ps Skin Lesion 1TA2B USMLE Step 2 CK Forum 1 04-10-2011 10:25 AM
skin disease khushboo USMLE Step 1 Forum 7 05-23-2010 11:40 AM

RSS Feed
Find Us on Facebook
vBulletin Security provided by vBSecurity v2.2.2 (Pro) - vBulletin Mods & Addons Copyright © 2017 DragonByte Technologies Ltd.

USMLE® & other trade marks belong to their respective owners, read full disclaimer
USMLE Forums created under Creative Commons 3.0 License. (2009-2014)