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Old 11-07-2012
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Question Glucagon activates Insulin?

DIT mentioned that that Glucagon activates Insulin.
Pls how is this possible??I believed it inactivates Insulin instead.
Can any kind soul shed some light on this..thank you
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Old 11-07-2012
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No response guys........??????????
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Old 11-07-2012
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Default Glucagon activates Insulin

Glucagon has no direct effect on Insulin. However since Glucagon increases blood sugar levels, that indirectly stimulates insulin. Both Glucagon and Insulin are part of feedback to maintain Blood sugar levels.
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Old 11-07-2012
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Glucagon increases glucose in blood ( via gluconeogenesis and glycogenolysis)

It is the rise in glucose that stimulates release of insulin ..

The response is indirect ...

Check the third thread out at the end of the page but don't get confused .
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Old 11-07-2012
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Quote:
Originally Posted by Arunabha View Post
Glucagon has no direct effect on Insulin. However since Glucagon increases blood sugar levels, that indirectly stimulates insulin. Both Glucagon and Insulin are part of feedback to maintain Blood sugar levels.
@arunabha@Alice thanx guys
But in hypoglycemia,glucagon inhibits insulin & activates it in hyperglyc.?

They are saying it's an error in FA but I doubt
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Old 11-07-2012
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Quote:
Originally Posted by chux View Post
@arunabha@Alice thanx guys
But in hypoglycemia,glucagon inhibits insulin & activates it in hyperglyc.?

They are saying it's an error in FA but I doubt
ya buddy, they act via feedback mechanisms mutually IMO.......

F.A changed it too(not only DIT)......verify in F.A errata---changed to glucagon increase insulin release

hope it clears

Last edited by venky2600; 11-07-2012 at 02:46 PM.
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Old 07-06-2013
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There is also another explanation (given in KLN).

Glucagon has amino acid sequence similar to that of secretin. Like secretin glucagon activates insulin.
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