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  #1  
Old 11-08-2012
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Immunology Child missing IL12

T lymphocytes from a 4 year old male with severe recurrent respiratory tract infections are found to have lack IL10 receptors. Supplementation with which of the following substances results in worsening of the following conditions.
a) Ig G
b) Erythropoetin
c) IL-2
D) GM-CSF
E) IFN GAMMA
F) COMPLEMENTS
G) IL-10
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  #2  
Old 11-08-2012
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Default EE

E...this pxt has selective IgA deficiency?gamma globulin will trigger anaphylactic rxn
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Old 11-08-2012
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ya, E) IFN-gamma(TH1) inhibit TH2 (IL10 and also IL4,5)

thanks
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Old 11-08-2012
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Quote:
Originally Posted by rupesh View Post
t lymphocyte from a 4 year old male with severe recurrent respiratory tract infections are found to have lack il10 receptors .supplementation with which of the following substances results in worsening of the following conditions.
a)Ig G
b)Erythropoetin
c)IL-2
D)GM-CSF
E)IFN GAMMA
F)COMPLEMENTS
G)IL-10
c) IL-2
Because IL-10 normally inhibits the TH1 response so right now this is unopposed in this child, an increase IL-2 would exaggerate the TH1 response even more, causing more cell damage by activating the whole shebang
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Old 11-08-2012
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Quote:
Originally Posted by rupesh View Post
t lymphocyte from a 4 year old male with severe recurrent respiratory tract infections are found to have lack il12 receptors .supplementation with which of the following substances results in worsening of the following conditions.
a)Ig G
b)Erythropoetin
c)IL-2
D)GM-CSF
E)IFN GAMMA
F)COMPLEMENTS
G)IL-10
sorry guys my typing mistake its IL 12 instead of IL10....

Last edited by rupesh; 11-08-2012 at 06:32 AM. Reason: MY TYPING MISTAKE
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Old 11-08-2012
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Quote:
Originally Posted by rupesh View Post
sorry guys my typing mistake its IL 12 instead of IL10....
ok.....then i'm not sure...going with E) IL10 by looking at below post.

thanks

Last edited by venky2600; 11-08-2012 at 06:53 AM.
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Old 11-08-2012
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Originally Posted by rupesh View Post
sorry guys my typing mistake its IL 12 instead of IL10....
IL-10; because this child is missing IL-12 which normally activates the CD8+ response, anything that will inhibit TH1 response (which eventually activates CD8) will make things more complicated for the child.
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  #8  
Old 11-08-2012
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The kid is missing IL-12

Quote:
Originally Posted by The Normal
Virus infected cells secret IL-12 acts on TH1 cells to release IL-2 and IFN-gamma
Quote:
Originally Posted by The Immunopathology
Because this kid lacks IL-12, CD8 activity & Cytotoxic Killing is inactive
This disorder is IL-12 receptor deficiency, they are prone to Disseminated mycobacterial infections due to lack of IFN-gamma
Your question is asking "What will worsen this kid?"
We can right off the bat rule out EPO, G-CSF, B-cells, since it has nothing to do with the question.
Choices IL-2 and IFN-gamma when given will "help" the kid, but the question is seeking, what will worsen the kid.

It would be (G) IL-10 because IL-10 commonly down regulates T-cells and TH1 cells. It is also well known that IL-10 and TGF-beta down-regulate local cytokine productions.
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Old 11-08-2012
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Default My answer g

IL4 and IL10 inhibit TH1 (IFN gamma,IL2,TNF-B)
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IL-12 induces differentiation of T cells to TH1 cells, in the case of IL-12 deficiency(decrease TH1 response) patient have disseminated mycobacterial infections.
TH1 cells produce IFN gamma,TNF betta and IL-2
TH2 cells produce IL-4 IL-5 IL-6 IL-10
IFN gamma produced by TH1 inhibits TH2
IL-4 AND IL-10 produced by TH2 inhibits TH1

SO MY ANSWER IS G)IL-10
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  #11  
Old 11-08-2012
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Correct Answer g

the answer to this question lies in the concept that IL 12 causes production of TH1 this TH1 is inhibited by IL 10 and activated by IFN gamma
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Old 11-09-2012
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can anyone please tell me how to start a thread here? im new here and i want to ask some questions but i cant find the option to start a new tag. thats why i had to post here.
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Old 11-09-2012
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can anyone please tell me how to start a thread here? im new here and i want to ask some questions but i cant find the option to start a new thread. thats why i had to post here.
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  #14  
Old 11-09-2012
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Quote:
Originally Posted by wertheworld11 View Post
can anyone please tell me how to start a thread here? im new here and i want to ask some questions but i cant find the option to start a new tag. thats why i had to post here.
hey werthe world 11 you can enter step 1 thread and click start a new thread at the top of the page....
u r welcome....
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