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  #1  
Old 11-10-2012
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Zygote Septum Primum Embryology!

A 20 year patient presents with shortness of breath on exertion. on examination he is found to have wide splitting of second heart sound. physician confirms it to be defect in septum primum. Pathology lies in?
a) apoptosis of septum primum
b) migration of septum primum to enndocardial cushions
c) defect in neural crest migration
d) defect in sinus venosus
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  #2  
Old 11-11-2012
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Default my answer :)

c)defect in neural crest migration
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  #3  
Old 11-11-2012
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my answer.....apoptosis of septum primum
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  #4  
Old 11-11-2012
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i will go for C
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Old 11-11-2012
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Default enbryo

i would go with option b
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Old 11-11-2012
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A. Apoptosis of septum primum
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Old 11-11-2012
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please post the answer
thanks
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Old 11-11-2012
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Default c

defect in endocardial cushion to migrate upward direction(or defect in neural crest migration coz endocardial cushion is made from neural crest)>>>>>>>septum primum type ASD...
OPTION A>>excessive apoptosis of septum primum results in septum secondum type ASD...
THANKS....
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Thanks
i did not know this
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Old 11-11-2012
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this is kaplan concept...
however most common type is septum secondum ASD......
THANX....
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Old 11-13-2012
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Default here is the answer

1.apoptosis(excess resorption) of septum primum results in septum secundum defect,which is MC type of ASD
2.Failure of migration of Septum primum to endocardial cushions results in ASD of septum primum type
3.Failure of migration of neural crest cells result in defect in development of Aorticopulmonary septum and also cause VSD, it has no relation with ASD

so my answer would be the second point here, which is responsible for septum primum type ASD


reference from anatomy kaplan book in thorax chapter,development of heart
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  #12  
Old 11-14-2012
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i am going with bbbbbbbb
could any one correct me if i am wrong
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