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Old 11-18-2012
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Arrow Billy Step 1 Questions # 85

A 25-year-old woman with a history of recurrent upper respiratory infections presents to her physician with her fifth such infection in the past year. She mentions that she may be getting sick due to increased stress at home,she and her husband have been trying to conceive unsuccessfully for several years. The patient’s WBC count, immunoglobulin, and platelet levels are within normal limits. Which organizational unit represents the structure most likely to be defective in this patient?


(A) Central pair with nine peripheral pairs of microtubules
(B) Collagen α chains in triplets
(C) Multilobular nucleus with enzyme-fi lled granules
(D) Numerous adjoining e-cadherin molecules with actin filaments
(E) Two longer heavy chains and two shorter light chains linked by disulfide bonds
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Default katagener syndrome

AA...ciliary dienin arm defect
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Default my answer :)

(A) Central pair with nine peripheral pairs of microtubules - Kartagener s.
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(A) Central pair with nine peripheral pairs of microtubules - Kertagener's syndrome
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Old 11-18-2012
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Default A?

Is it normal not to know the answer at all until you read the choices?? Coz that happens to me a lot. I'm taking a guess at A here
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Correct Answer A is correct

This woman has Kartagener’s syndrome, which is a caused by a defect in microtubule dynein, resulting in immotile cilia. Loss of cilial “sweeping” renders women infertile because eggs are not advanced through the fallopian tubes; it also results in an increased incidence of upper respiratory infections as the loss of mucociliary clearance allows debris to accumulate in the airway. Cilia have a distinct organization, with a central pair of microtubules and nine surrounding pairs, allowing them to bend and sway by differential sliding of the pairs.
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Old 11-18-2012
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Quote:
Originally Posted by billy View Post
A 25-year-old woman with a history of recurrent upper respiratory infections presents to her physician with her fifth such infection in the past year. She mentions that she may be getting sick due to increased stress at home,she and her husband have been trying to conceive unsuccessfully for several years. The patient’s WBC count, immunoglobulin, and platelet levels are within normal limits. Which organizational unit represents the structure most likely to be defective in this patient?


(A) Central pair with nine peripheral pairs of microtubules
(B) Collagen α chains in triplets
(C) Multilobular nucleus with enzyme-fi lled granules
(D) Numerous adjoining e-cadherin molecules with actin filaments
(E) Two longer heavy chains and two shorter light chains linked by disulfide bonds

(A) Central pair with nine peripheral pairs of microtubules

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Originally Posted by billy View Post
This woman has Kartagener’s syndrome, which is a caused by a defect in microtubule dynein, resulting in immotile cilia. Loss of cilial “sweeping” renders women infertile because eggs are not advanced through the fallopian tubes; it also results in an increased incidence of upper respiratory infections as the loss of mucociliary clearance allows debris to accumulate in the airway. Cilia have a distinct organization, with a central pair of microtubules and nine surrounding pairs, allowing them to bend and sway by differential sliding of the pairs.
Females with Kertagener's syndrome are fertile, because the smooth muscle in fallopian tubes is responsible for pushing the eggs and then zygote to the uterine cavity. This is reinforced by the secretion of fluid by non-ciliated cells, as a result a wave of fluid is created which carries eggs towards the cavity.
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Old 11-19-2012
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C) Multilobular nucleus with enzyme-fi lled granules
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