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Old 11-18-2012
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Genetics pedigree chart genetics question

A 35 year old man presents to your office for genetic counselling. He has h/o progressive dementia, loss of motor control and affective disorder. His family tree is given below.
What is the most likely explanation for the pedigree finding?

a. anticipation
b. incomplete penetrance
c. variable expressivity
d. pleitrophy
e. genetic heterogenicity
f. genetic linkage
g. polyploidy
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  #2  
Old 11-18-2012
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A. Anticipation.
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Old 11-18-2012
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Default my answer :)

a. anticipation
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Old 11-18-2012
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My answer is A
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Old 11-19-2012
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My answer is B. Incompelete penetrance.
hungtingtons disease AD disorder and should be present in every generation. As one generation is skipped. So its incompelte penetrance.!
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Old 11-19-2012
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Quote:
Originally Posted by wertheworld11 View Post
A 35 year old man presents to your office for genetic counselling. He has h/o progressive dementia, loss of motor control and affective disorder. His family tree is given below.
What is the most likely explanation for the pedigree finding?

a. anticipation
b. incomplete penetrance
c. variable expressivity
d. pleitrophy
e. genetic heterogenicity
f. genetic linkage
g. polyploidy
Anticipation


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Old 11-19-2012
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if its anticipation it should be represented in 1 st generation also but its missing and it should be progressively worse in each generation, so how one gneration can be skiped, so i go with B....
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