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Old 11-19-2012
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Question Hypotonic gain of Na

I came across this in Goljan

Net gain of H2O in excess of Na

TBNa increases / TBW increases more

Conditions
1. Right sided heart failure
2. Cirrhosis
3. Nephrotic syndrome

RHF increases veinous pressure and last two conditions decreases oncotic pressure.

How can these conditions increase total body sodium, mean gain in Na however small it may be as compare to water?
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Old 11-19-2012
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Quote:
Originally Posted by MBBS View Post
I came across this in Goljan

Net gain of H2O in excess of Na

TBNa increases / TBW increases more

Conditions
1. Right sided heart failure
2. Cirrhosis
3. Nephrotic syndrome

RHF increases veinous pressure and last two conditions decreases oncotic pressure.

How can these conditions increase total body sodium, mean gain in Na however small it may be as compare to water?
These three conditions cause transudate with pitting edema,the juxtaglomerula cell responds-->increase Renin angiotensin aldosterone system--->increase Sodium retention(hypernitremia)hypokalemia and alkalosis.
Eventually,atria naturetic peptide will be released by the atria--->natuiresis (aldosterone rescue)

End result will be euvolemic hypernatremia
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Old 11-20-2012
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Quote:
Originally Posted by blade View Post
These three conditions cause transudate with pitting edema,the juxtaglomerula cell responds-->increase Renin angiotensin aldosterone system--->increase Sodium retention(hypernitremia)hypokalemia and alkalosis.
Eventually,atria naturetic peptide will be released by the atria--->natuiresis (aldosterone rescue)

End result will be euvolemic hypernatremia
Thanks. So basically Na is retained.
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