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  #1  
Old 11-28-2012
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Neuro Dopamin and the Basal Ganglia!

In the first aid, Dopamine's effect on the Inhibitory Pathway is to 'inhibit the inhibition', which results in motion.

But in Kaplan, he says that Dopamine causes motion in the Direct Pathway (which makes sense), but causes inhibition in the indirect pathway. (no motion).

So First Aid says that Dopamine has the same net effect in both pathways. But Kaplan says that Dopamine has opposite effects in each pathway.

I'm just really confused now. Any good sources outside of Kaplan/First Aid to help me understand the basal ganglia. I sort of flew by this in med school, but now I really want to get the concept down.
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Old 11-28-2012
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so i found this link just now, http://www.neuroanatomy.wisc.edu/coursebook/motor2.pdf

is this a little too much? or is it worth reading, just to nail the concepts of the basal ganglia?
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Old 11-28-2012
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so i started reading the link above. its all making sense now!!

but i have noticed a glaring mistake in first aid 2010

Ach released within the striatum INHIBIT the direct pathway. and they EXCITE the indirect pathway.

But in the FA book, it illustrates that Ache excites Both pathways. which is incorrect.
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Old 11-28-2012
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Quote:
Originally Posted by ReggieMiller View Post

i have noticed a glaring mistake in first aid 2010

Ach released within the striatum INHIBIT the direct pathway. and they EXCITE the indirect pathway.

But in the FA book, it illustrates that Ach excites Both pathways. which i believe is incorrect.
just looked over the errata for 2010, but no mention of the above. http://firstaidteam.com/wp-content/u...ta-1009291.pdf

i finally feel i have a very good grasp of the basal ganglia, all connections, and clinical correlations with Parkinsons, Hemibalismus, and Huntingtons'.

its just that the figure in First Aid is really annoying me, because its showing that the interneurons (Ach) excite BOTH the direct and indirect pathway. which i believe is wrong.

thanks.
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Old 12-17-2012
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Im looking at first aid right now for the dopamine pathways.
Its really annoying.
Who makes stimulatory color red and inhibitory color green?
From what planet is green stop?
I feel they do this on purpose to annoy us.
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Old 10-03-2014
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Default Correction

Dopamine always promote movement:
1st: by activating direct pathway
Dopamine binds D1 in the striatum inhibiting the GPi so it can't inhibit the thalamus, leading to movement.

2nd: by inhibiting indirect pathway
Dopamine binds D2 in the striatum so Putamen can't inhibit GPe which now is going to inhibit STN so it won't stimulate GPi then the thalamus won't be inhibited also leading to movement.
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